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Nuclear Envelope and Nuclear Pore Complexes in Neurodegenerative Diseases—New Perspectives for Therapeutic Interventions
Transport of proteins, transcription factors, and other signaling molecules between the nucleus and cytoplasm is necessary for signal transduction. The study of these transport phenomena is particularly challenging in neurons because of their highly polarized structure. The bidirectional exchange of...
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| Published in: | Molecular neurobiology 2021-03, Vol.58 (3), p.983-995 |
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| Main Authors: | , , , , , , |
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| container_title | Molecular neurobiology |
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| creator | Hachiya, Naomi Sochocka, Marta Brzecka, Anna Shimizu, Takuto Gąsiorowski, Kazimierz Szczechowiak, Katarzyna Leszek, Jerzy |
| description | Transport of proteins, transcription factors, and other signaling molecules between the nucleus and cytoplasm is necessary for signal transduction. The study of these transport phenomena is particularly challenging in neurons because of their highly polarized structure. The bidirectional exchange of molecular cargoes across the nuclear envelope (NE) occurs through nuclear pore complexes (NPCs), which are aqueous channels embedded in the nuclear envelope. The NE and NPCs regulate nuclear transport but are also emerging as relevant regulators of chromatin organization and gene expression. The alterations in nuclear transport are regularly identified in affected neurons associated with human neurodegenerative diseases. This review presents insights into the roles played by nuclear transport defects in neurodegenerative disease, focusing primarily on NE proteins and NPCs. The subcellular mislocalization of proteins might be a very desirable means of therapeutic intervention in neurodegenerative disorders. |
| doi_str_mv | 10.1007/s12035-020-02168-x |
| format | article |
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The study of these transport phenomena is particularly challenging in neurons because of their highly polarized structure. The bidirectional exchange of molecular cargoes across the nuclear envelope (NE) occurs through nuclear pore complexes (NPCs), which are aqueous channels embedded in the nuclear envelope. The NE and NPCs regulate nuclear transport but are also emerging as relevant regulators of chromatin organization and gene expression. The alterations in nuclear transport are regularly identified in affected neurons associated with human neurodegenerative diseases. This review presents insights into the roles played by nuclear transport defects in neurodegenerative disease, focusing primarily on NE proteins and NPCs. The subcellular mislocalization of proteins might be a very desirable means of therapeutic intervention in neurodegenerative disorders.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-020-02168-x</identifier><identifier>PMID: 33067781</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Active Transport, Cell Nucleus ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Chromatin ; Cytoplasm ; Gene expression ; Humans ; Neurobiology ; Neurodegenerative diseases ; Neurodegenerative Diseases - metabolism ; Neurodegenerative Diseases - therapy ; Neurology ; Neurosciences ; Nuclear Envelope - metabolism ; Nuclear Pore - metabolism ; Nuclear Pore Complex Proteins - metabolism ; Nuclear transport ; Protein transport ; Proteins ; RNA Transport ; Signal transduction ; Therapeutic applications ; Transcription factors</subject><ispartof>Molecular neurobiology, 2021-03, Vol.58 (3), p.983-995</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. 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| ispartof | Molecular neurobiology, 2021-03, Vol.58 (3), p.983-995 |
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| language | eng |
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| source | Springer Nature |
| subjects | Active Transport, Cell Nucleus Animals Biomedical and Life Sciences Biomedicine Cell Biology Chromatin Cytoplasm Gene expression Humans Neurobiology Neurodegenerative diseases Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - therapy Neurology Neurosciences Nuclear Envelope - metabolism Nuclear Pore - metabolism Nuclear Pore Complex Proteins - metabolism Nuclear transport Protein transport Proteins RNA Transport Signal transduction Therapeutic applications Transcription factors |
| title | Nuclear Envelope and Nuclear Pore Complexes in Neurodegenerative Diseases—New Perspectives for Therapeutic Interventions |
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