The Effects of Copper Constituent of Coin Currency on Embryonic Zebrafish Development

Copper has demonstrated utility in multiple industrial applications for its high conductivity and antibacterial/antiviral properties. However, numerous findings have suggested potential hazards regarding pathogenesis. This study was conducted to demonstrate the application of zebrafish (Danio rerio)...

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Bibliographic Details
Published in:BioMed research international 2021, Vol.2021 (1), p.2134928
Main Authors: Hong, Ted Inpyo, Kang, Seo-Gu, Lee, Yu-Ri, Choi, Tae-Ik, Kim, Woo-Keun, Kim, Cheol-Hee
Format: Article
Language:English
Subjects:
Analytical methods
Antiviral activity
Bioassays
Biological effects
Cell culture
Coins
Copper
Danio rerio
Drinking water
Embryogenesis
Embryonic development
Embryos
Environment
Environmental aspects
Environmental monitoring
Experiments
Health aspects
Heavy metals
Industrial applications
Larvae
Life sciences
Materials
Mortality
Organic contaminants
Pathogenesis
Phenotypes
Physiological aspects
Pollution detection
Pollution effects
Toxicity
Water monitoring
Water pollution
Water quality
Zebra fish
Zebrafish
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Summary:Copper has demonstrated utility in multiple industrial applications for its high conductivity and antibacterial/antiviral properties. However, numerous findings have suggested potential hazards regarding pathogenesis. This study was conducted to demonstrate the application of zebrafish (Danio rerio) as a cost-effective biological assay to detect environmental pollution, i.e., heavy metal of coins. We demonstrated that zebrafish larvae exposed to copper-plated coins or copper (II) ion solution elicited a consistent phenotype of early mortality without signs of morphological defects in surviving individuals. Copper ion solution served as a standard to (1) corroborate copper exposure from coins and (2) demonstrate proportional increase in early mortality phenotype according to concentration. We found that 5 μM CuSO4·5H2O was the minimal concentration to elicit the observed phenotypes from copper toxicity. This study aimed to demonstrate how a simple protocol involving wild-type zebrafish larvae could provide an economical solution to water monitoring in areas of rapid technological advancement and increasing environmental concerns, especially in communities without access to expensive analytical methods.
ISSN:2314-6133
2314-6141
DOI:10.1155/2021/2134928