Study of long non-coding RNA highly upregulated in liver cancer (HULC) in breast cancer: A clinical & in vitro investigation

Background & objectives: Breast cancer remains the most common malignancy among women worldwide. Long non-coding RNAs (lncRNAs) have been shown to play critical roles in tumour initiation and progression. This study was aimed to evaluate the potential role of lncRNA highly upregulated in liver c...

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Published in:Indian journal of medical research (New Delhi, India : 1994) India : 1994), 2020-09, Vol.152 (3), p.244-253
Main Authors: Gavgani, Reyhaneh, Babaei, Esmaeil, Hosseinpourfeizi, Mohammad, Fakhrjou, Ashraf, Montazeri, Vahid
Format: Article
Language:English
Subjects:
Biomarkers
Breast cancer
Breast Neoplasms - genetics
Cancer research
Cell Movement - genetics
Development and progression
EDTA
Female
Gene Expression Regulation, Neoplastic
Humans
Investigations
Liver cancer
Liver Neoplasms - genetics
Original
RNA
RNA, Long Noncoding - genetics
Transcription (Genetics)
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Summary:Background & objectives: Breast cancer remains the most common malignancy among women worldwide. Long non-coding RNAs (lncRNAs) have been shown to play critical roles in tumour initiation and progression. This study was aimed to evaluate the potential role of lncRNA highly upregulated in liver cancer (HULC) in breast cancer. Methods: The expression of HULC was evaluated in breast cancer patients and cell lines using real-time quantitative reverse transcription polymerase chain reaction. Small interfering RNA-based knockdown was also employed to study the potential role of HULC in breast cancer cell lines including ZR-75-1, MCF7 and MDA-MB-231. Results: HULC was significantly upregulated in tumour tissues compared to non-tumoural margins (P
ISSN:0971-5916
0975-9174
DOI:10.4103/ijmr.IJMR_1823_18