Safety and tolerability of repeated sessions of deep transcranial magnetic stimulation in obesity

Purpose Repetitive Transcranial Magnetic Stimulation (rTMS) has been demonstrated to be effective in body weight control in individuals with obesity. Most clinical trials on rTMS provided a reassuring safety profile. In the present work, we present an extensive analysis on both severe and mild Adver...

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Bibliographic Details
Published in:Endocrine 2021-02, Vol.71 (2), p.331-343
Main Authors: Ferrulli, Anna, Massarini, Stefano, Macrì, Concetta, Luzi, Livio
Format: Article
Language:English
Subjects:
Adverse events
Body weight
Clinical trials
Diabetes
Drowsiness
Endocrinology
Headache
Humanities and Social Sciences
Internal Medicine
Magnetic fields
Medicine
Medicine & Public Health
multidisciplinary
Obesity
Original
Original Article
Pain
Paresthesia
Patients
Safety
Science
Side effects
Sleep disorders
Transcranial magnetic stimulation
Weight control
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Summary:Purpose Repetitive Transcranial Magnetic Stimulation (rTMS) has been demonstrated to be effective in body weight control in individuals with obesity. Most clinical trials on rTMS provided a reassuring safety profile. In the present work, we present an extensive analysis on both severe and mild Adverse Events (AEs) in obese individuals treated with rTMS. Methods We examined the intensity, duration, correlation with the treatment, up to 1 year after the end of rTMS treatment. Results Descriptive analysis included a total of 63 subjects undergoing a 5-week deep rTMS experimental treatment for obesity (age 48.3 ± 10.4 years; BMI 36.3 ± 4.4 kg/m 2 ): 31 patients were treated with high-frequency rTMS (HF), 13 with low-frequency rTMS (LF), and 19 were sham treated (Sham). Thirty-two subjects (50.8%) reported a total of 52 AEs, including mainly moderate (51.9%) events. The most frequently reported side effects were headaches of moderate intensity (40.4%) and local pain/discomfort (19.2%) and resulted significantly more frequent in HF group compared to other groups ( p  
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-020-02496-x