Viral mouse models used to study multiple sclerosis: past and present

Multiple sclerosis (MS) is a common inflammatory demyelinating disease of the central nervous system. Although the etiology of MS is unknown, genetics and environmental factors, such as infections, play a role. Viral infections of mice have been used as model systems to study this demyelinating dise...

Full description

Saved in:
Bibliographic Details
Published in:Archives of virology 2021-04, Vol.166 (4), p.1015-1033
Main Authors: Libbey, J. E., Fujinami, R. S.
Format: Article
Language:English
Subjects:
Animal models
Animals
Biomedical and Life Sciences
Biomedicine
Central nervous system
Central Nervous System - pathology
Central Nervous System - physiology
Central Nervous System - virology
Demyelinating diseases
Demyelination
Disease Models, Animal
Encephalomyelitis
Environmental factors
Etiology
Hepatitis
Humans
Infectious Diseases
Medical Microbiology
Mice
Multiple sclerosis
Multiple Sclerosis - immunology
Multiple Sclerosis - pathology
Multiple Sclerosis - physiopathology
Multiple Sclerosis - virology
Murine hepatitis virus - pathogenicity
Murine hepatitis virus - physiology
Review
RNA Virus Infections - immunology
RNA Virus Infections - pathology
RNA Virus Infections - physiopathology
RNA Virus Infections - virology
Semliki forest virus - pathogenicity
Semliki forest virus - physiology
Theilovirus - pathogenicity
Theilovirus - physiology
Viral infections
Virology
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Multiple sclerosis (MS) is a common inflammatory demyelinating disease of the central nervous system. Although the etiology of MS is unknown, genetics and environmental factors, such as infections, play a role. Viral infections of mice have been used as model systems to study this demyelinating disease of humans. Three viruses that have long been studied in this capacity are Theiler’s murine encephalomyelitis virus, mouse hepatitis virus, and Semliki Forest virus. This review describes the viruses themselves, the infection process, the disease caused by infection and its accompanying pathology, and the model systems and their usefulness in studying MS.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-021-04968-5