Selective vulnerability of inhibitory networks in multiple sclerosis

In multiple sclerosis (MS), a chronic demyelinating disease of the central nervous system, neurodegeneration is detected early in the disease course and is associated with the long-term disability of patients. Neurodegeneration is linked to both inflammation and demyelination, but its exact cause re...

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Bibliographic Details
Published in:Acta neuropathologica 2021-03, Vol.141 (3), p.415-429
Main Authors: Zoupi, Lida, Booker, Sam A., Eigel, Dimitri, Werner, Carsten, Kind, Peter C., Spires-Jones, Tara L., Newland, Ben, Williams, Anna C.
Format: Article
Language:English
Subjects:
Aged
Animals
Brain
Brain - pathology
Central nervous system
Demyelinating diseases
Demyelinating Diseases - pathology
Demyelination
Female
Humans
Inflammation
Interneurons
Male
Medicine
Medicine & Public Health
Mice
Mice, Inbred C57BL
Middle Aged
Multiple sclerosis
Multiple Sclerosis, Chronic Progressive - pathology
Nerve Degeneration - pathology
Neurodegeneration
Neurons
Neurons - pathology
Neuroprotection
Neurosciences
Original Paper
Pathology
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Summary:In multiple sclerosis (MS), a chronic demyelinating disease of the central nervous system, neurodegeneration is detected early in the disease course and is associated with the long-term disability of patients. Neurodegeneration is linked to both inflammation and demyelination, but its exact cause remains unknown. This gap in knowledge contributes to the current lack of treatments for the neurodegenerative phase of MS. Here we ask if neurodegeneration in MS affects specific neuronal components and if it is the result of demyelination. Neuropathological examination of secondary progressive MS motor cortices revealed a selective vulnerability of inhibitory interneurons in MS. The generation of a rodent model of focal subpial cortical demyelination reproduces this selective neurodegeneration providing a new preclinical model for the study of neuroprotective treatments.
ISSN:0001-6322
1432-0533
DOI:10.1007/s00401-020-02258-z