Time intervals between semen production, initiation of analysis, and IUI significantly influence clinical pregnancies and live births

• Published in: Journal of assisted reproduction and genetics 2021-02, Vol.38 (2), p.421-428
• Main Authors: Punjabi, U., Van Mulders, H., Van de Velde, L., Goovaerts, I., Peeters, K., Cassauwers, W., Lyubetska, T., Clasen, K., Janssens, P., Zemtsova, O., Roelant, E., De Neubourg, D.
• Format: Article
• Language: English
• Subjects: Adult; Assisted Reproduction Technologies; Birth Rate; Births; Centrifugation; Female; Fertility; Gynecology; Human Genetics; Humans; Insemination, Artificial, Homologous; Live Birth - genetics; Male; Medicine; Medicine & Public Health; Pregnancy; Pregnancy Outcome - genetics; Pregnancy Rate; Reproductive Medicine; Semen; Semen - cytology; Semen - metabolism; Sperm Count - methods
• ISSN: 1058-0468; 1573-7330; 1573-7330
• DOI: 10.1007/s10815-020-02020-0

Purpose Does IDEF mapping help monitor the technical process of IUI and explore the potential improvements which might contribute to increased pregnancy and live birth rates? Method Retrospective analysis of 1729 homologous IUI cycles of couples attending a fertility clinic in a university hospital setting. Standardized conventional semen parameters were analyzed and the semen samples prepared via discontinuous density gradient centrifugation. Results There was no significant association between sperm concentration, motility and morphology (analysis phase), and pregnancy outcome. Only female and male ages were significantly associated with the pregnancy outcome. There was a significant difference in the odds on clinical pregnancies and live births when analysis was ≤ 21 min initiated, and