A Unique Case of Combined Nodular and Tracheobronchial Amyloidosis

ABSTRACT Amyloidosis is a heterogeneous group of diseases characterized by the extracellular deposition of misfolded proteins that can affect either systemically or locally confined to one system. Pulmonary amyloidosis is rare and can be classified into three forms according to the anatomic site of...

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Bibliographic Details
Published in:Oxford Medical Case Reports 2021-02, Vol.2021 (2), p.omaa134
Main Authors: Ding, Feihong, Li, Yun, Balasubramanian, Shailesh, Ghosh, Subha, Valent, Jason N, Almeida, Francisco, Arrossi, A Valeria, Mehta, Atul
Format: Article
Language:English
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Case Report
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Summary:ABSTRACT Amyloidosis is a heterogeneous group of diseases characterized by the extracellular deposition of misfolded proteins that can affect either systemically or locally confined to one system. Pulmonary amyloidosis is rare and can be classified into three forms according to the anatomic site of involvement: nodular pulmonary amyloidosis, tracheobronchial amyloidosis and diffuse alveolar-septal amyloidosis. The former two usually represent localized amyloid disease and the latter represents systemic disease. Typically lung parenchymal and tracheobronchial amyloidosis do not present together in localized forms of pulmonary amyloidosis. Here we report a unique case of localized pulmonary immunoglobulin light-chain amyloidosis, manifested as both parenchymal nodules and tracheobronchial amyloid deposition.
ISSN:2053-8855
2053-8855
DOI:10.1093/omcr/omaa134