Oncogenic mechanisms in renal insufficiency

Abstract The prevalence of both cancer and end-stage renal disease is increasing. In addition, medical advances have meant increased survival rates for both diseases. Many chemotherapeutics are renally excreted, and conversely, renal insufficiency promotes a pro-neoplastic state, including genitouri...

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Bibliographic Details
Published in:Clinical Kidney Journal 2021-02, Vol.14 (2), p.507-515
Main Authors: Volovat, Simona Ruxandra, Volovat, Constantin, Miron, Ingrith, Kanbay, Mehmet, Goldsmith, David, Lungulescu, Cristian, Badarau, Silvia Corina, Covic, Adrian
Format: Article
Language:English
Subjects:
B cells
Cancer
Cardiovascular diseases
Chronic kidney failure
CKJ Reviews
Development and progression
Epidemiology
Health aspects
Oncology, Experimental
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Summary:Abstract The prevalence of both cancer and end-stage renal disease is increasing. In addition, medical advances have meant increased survival rates for both diseases. Many chemotherapeutics are renally excreted, and conversely, renal insufficiency promotes a pro-neoplastic state, including genitourinary and other cancers. Dialysis prolongs life while increasing cancer risk. Proposed oncogenic mechanisms include immune dysfunction, chronic inflammation, changes in gut microbiota and stimulation of the renin–angiotensin system. This review summarizes current concepts in the relationship between cancer and renal insufficiency.
ISSN:2048-8505
2048-8513
DOI:10.1093/ckj/sfaa122