Comparative toxicokinetics of bisphenol S in rats and mice following gavage administration

• Published in: Toxicology and applied pharmacology 2020-11, Vol.406, p.115207-115207, Article 115207
• Main Authors: Waidyanatha, Suramya, Black, Sherry R., Silinski, Melanie, Sutherland, Vicki, Fletcher, Brenda L., Fernando, Reshan A., Fennell, Timothy R.
• Format: Article
• Language: English
• Subjects: Absorption; Administration, Intravenous; Administration, Oral; Animals; Biological Availability; Bisphenol S; Distribution; Elimination; Female; Male; Mice; Oral Bioavailability; Phenols - administration & dosage; Phenols - blood; Phenols - pharmacokinetics; Phenols - toxicity; Rats; Sex Characteristics; Sulfones - administration & dosage; Sulfones - blood; Sulfones - pharmacokinetics; Sulfones - toxicity; Toxicokinetics
• ISSN: 0041-008X; 1096-0333
• DOI: 10.1016/j.taap.2020.115207

Bisphenol S (BPS) is a component of polyether sulfone used in a variety of industrial applications and consumer products. We investigated the plasma toxicokinetic (TK) behavior of free (unconjugated parent) and total (parent and conjugated) BPS in rats and mice following a single gavage administration (34, 110, or 340 mg/kg). In male rats, BPS was rapidly absorbed with free BPS maximum concentration (Cmax) reached at ≤2.27 h. Elimination of free BPS in male rats was dose-dependent with estimated half-lives of 5.77–11.9 h. Cmax and area under the concentration versus time curve (AUC) increased with dose although the increase in AUC was more than dose proportional. In male rats, total BPS Cmax was reached ≤2.77 h with both Cmax (≥ 10-fold) and AUC (≥ 15-fold) higher than free BPS demonstrating rapid and extensive conjugation of BPS. In male mice, the increase in Cmax and AUC of free BPS was dose-proportional; Cmax was higher and AUC was lower than in male rats. BPS was cleared more rapidly in male mice (half-life 2.86–4.21 h) compared to male rats (half-life 5.77–11.9 h). Similar to rats, total BPS Cmax (≥ 6-fold) and AUC (≥ 12-fold) were higher than corresponding free BPS. Oral bioavailability of free BPS was low to moderate (rats, ≤ 21%; mice, ≤ 19%). There were some species differences in TK parameters of free and total BPS and limited sex difference in rats and mice. In addition, there were dose-related effects of plasma TK parameters in rats. •Bisphenol S (BPS) is a structural analogue of bisphenol A.•We investigated the toxicokinetics of BPS in rodents via gavage exposure.•BPS was rapidly absorbed in rodents following gavage exposure.•Plasma elimination was rapid in mice compared to rats.•BPS was highly conjugated with low to moderate bioavailability.