Optoretinogram: optical measurement of human cone and rod photoreceptor responses to light

Noninvasive, objective measurement of rod function is as significant as that of cone function, and for retinal diseases such as retinitis pigmentosa and age-related macular degeneration, rod function may be a more sensitive biomarker of disease progression and efficacy of treatment than cone functio...

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Bibliographic Details
Published in:Optics letters 2020-09, Vol.45 (17), p.4658-4661
Main Authors: Azimipour, Mehdi, Valente, Denise, Vienola, Kari V, Werner, John S, Zawadzki, Robert J, Jonnal, Ravi S
Format: Article
Language:English
Subjects:
Adaptive optics
Adaptive systems
Age related diseases
Biomarkers
Cones
Eye diseases
Humans
Light
Medical imaging
Ophthalmoscopy - methods
Optical Coherence Tomography
Optical measurement
Photoreceptors
Retinal Cone Photoreceptor Cells - cytology
Retinal Cone Photoreceptor Cells - radiation effects
Retinal Rod Photoreceptor Cells - cytology
Retinal Rod Photoreceptor Cells - radiation effects
Rods
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Summary:Noninvasive, objective measurement of rod function is as significant as that of cone function, and for retinal diseases such as retinitis pigmentosa and age-related macular degeneration, rod function may be a more sensitive biomarker of disease progression and efficacy of treatment than cone function. Functional imaging of single human rod photoreceptors, however, has proven difficult because their small size and rapid functional response pose challenges for the resolution and speed of the imaging system. Here, we describe light-evoked, functional responses of human rods and cones, measured noninvasively using a synchronized adaptive optics optical coherence tomography (OCT) and scanning light ophthalmoscopy (SLO) system. The higher lateral resolution of the SLO images made it possible to confirm the identity of rods in the corresponding OCT volumes.
ISSN:0146-9592
1539-4794
DOI:10.1364/ol.398868