Advancement and properties of circular RNAs in prostate cancer: An emerging and compelling frontier for discovering

Prostate cancer (PC) is the most common carcinoma among men worldwide which results in 26% of leading causes of cancer-related death. However, the ideal and effective molecular marker remains elusive. CircRNA, initially observed in plant-infected viruses and Sendai virus in 1979, is generated from p...

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Bibliographic Details
Published in:International journal of biological sciences 2021-01, Vol.17 (2), p.651-669
Main Authors: Zhou, Hong, Zheng, Xu-Dong, Lin, Chang-Ming, Min, Jie, Hu, Shuang, Hu, Ying, Li, Liang-Yun, Chen, Jia-Si, Liu, Yu-Min, Li, Hao-Dong, Meng, Xiao-Ming, Li, Jun, Yang, Ya-Ru, Xu, Tao
Format: Article
Language:English
Subjects:
Androgens
Animals
Apoptosis
Biomarkers
Biomarkers, Tumor - metabolism
Cancer therapies
Carcinogenesis
Carcinogens
Carcinoma - metabolism
Epigenesis, Genetic
Epigenetics
Epithelial-Mesenchymal Transition
Genes
Genes, Tumor Suppressor
Humans
Male
Medical prognosis
Metastases
Metastasis
MicroRNAs
mRNA
Oncogenes
Pathogenesis
Prostate cancer
Prostatic Neoplasms - metabolism
Proteins
Review
RNA, Circular - metabolism
Splicing
Tumorigenesis
Tumors
Viruses
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Summary:Prostate cancer (PC) is the most common carcinoma among men worldwide which results in 26% of leading causes of cancer-related death. However, the ideal and effective molecular marker remains elusive. CircRNA, initially observed in plant-infected viruses and Sendai virus in 1979, is generated from pre-mRNA back-splicing and comes in to play by adequate expression. The differential expression in prostate tissues compared with the control reveals the promising capacity in modulating processes including carcinogenesis and metastasis. However, the biological mechanisms of regulatory network in PC needs to systemically concluded. In this review, we enlightened the comprehensive studies on the definite mechanisms of circRNAs affecting tumor progression and metastasis. What's more, we validated the potential clinical application of circRNAs serving as diagnostic and prognostic biomarker. The discussion and analysis in circRNAs will broaden our knowledge of the pathogenesis of PC and further optimize the current therapies against different condition.
ISSN:1449-2288
1449-2288
DOI:10.7150/ijbs.52266