Lactoferrin affects rhinovirus B-14 entry into H1-HeLa cells

Lactoferrin is part of the innate immune system, with antiviral activity against numerous DNA and RNA viruses. Rhinoviruses, the leading cause of the common cold, are associated with exacerbation of respiratory illnesses such as asthma. Here, we explored the effect of bovine lactoferrin (BLf) on RV-...

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Bibliographic Details
Published in:Archives of virology 2021-04, Vol.166 (4), p.1203-1211
Main Authors: Denani, Caio Bidueira, Real-Hohn, Antonio, de Carvalho, Carlos Alberto Marques, Gomes, Andre Marco de Oliveira, Gonçalves, Rafael Braga
Format: Article
Language:English
Subjects:
Adsorption
Antiviral activity
Antiviral Agents - metabolism
Antiviral Agents - pharmacology
Asthma
Biomedical and Life Sciences
Biomedicine
Brief Report
Cell Survival - drug effects
Common cold
Cytopathogenic Effect, Viral - drug effects
DNA viruses
Enterovirus - drug effects
Enterovirus - physiology
Enterovirus Infections - virology
HeLa Cells
Heparan sulfate
Humans
Immune system
Infections
Infectious Diseases
Infectivity
Innate immunity
Laboratories
Lactoferrin
Lactoferrin - metabolism
Lactoferrin - pharmacology
Medical Microbiology
Respiratory diseases
Rhinovirus
RNA viruses
Severe acute respiratory syndrome
Viral infections
Virology
Virus Attachment - drug effects
Virus Internalization - drug effects
Viruses
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Summary:Lactoferrin is part of the innate immune system, with antiviral activity against numerous DNA and RNA viruses. Rhinoviruses, the leading cause of the common cold, are associated with exacerbation of respiratory illnesses such as asthma. Here, we explored the effect of bovine lactoferrin (BLf) on RV-B14 infectivity. Using different assays, we show that the effect of BLf is strongest during adhesion of the virus to the cell and entry. Tracking the internalisation of BLf and virus revealed a degree of colocalisation, although their interaction was only confirmed in vitro using empty viral particles, indicating a possible additional influence of BLf on other infection steps.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-021-04993-4