Comparison of Elastography Point Quantification with Transient Elastography in Patients with Chronic Viral Hepatitis and Nonalcoholic Fatty Liver Disease: A Pilot Study

The objective of this study was to compare diagnostic accuracy of elastography point quantification (ElastPQ) with transient elastography (TE) and liver histology for measuring liver stiffness in patients with chronic viral hepatitis (CVH) and nonalcoholic fatty liver disease (NAFLD). Thirty-two pat...

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Bibliographic Details
Published in:Journal of clinical and experimental hepatology 2021-01, Vol.11 (1), p.21-29
Main Authors: Kapur, Savinay, Kalra, Naveen, Bhatia, Anmol, Duseja, Ajay, Das, Ashim, Dhiman, Radha K., Chawla, Yogesh, Sandhu, Manavjit S.
Format: Article
Language:English
Subjects:
CVH
ElastPQ
Fibroscan
NAFLD
Original
ultrasound elastography
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Summary:The objective of this study was to compare diagnostic accuracy of elastography point quantification (ElastPQ) with transient elastography (TE) and liver histology for measuring liver stiffness in patients with chronic viral hepatitis (CVH) and nonalcoholic fatty liver disease (NAFLD). Thirty-two patients with chronic liver disease (CVH and NAFLD) were evaluated by ElastPQ and TE within 7 days of liver biopsy. Within the CVH group, subgroup analysis was carried out in patients with end-stage renal disease (ESRD) and without ESRD. Area under the receiver operating characteristic (AUROC) curves were calculated for ElastPQ and TE. There were 15 patients with CVH and 17 patients with NAFLD. In the CVH group, there were 8 patients with ESRD and 7 patients without ESRD. Taking liver histopathology as the gold standard, liver stiffness measurement by ElastPQ (ρ = 0.826;P 
ISSN:0973-6883
2213-3453
DOI:10.1016/j.jceh.2020.06.005