Role of tranexamic acid in blood loss control and blood transfusion management of patients undergoing multilevel spine surgery: A meta-analysis

• Published in: Medicine (Baltimore) 2021-02, Vol.100 (7), p.e24678-e24678
• Main Authors: Zhao, Yibo, Xi, Chunyang, Xu, Wenxiao, Yan, Jinglong
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Antifibrinolytic Agents - administration & dosage; Antifibrinolytic Agents - therapeutic use; Blood Loss, Surgical - prevention & control; Blood Transfusion - standards; Blood Transfusion - statistics & numerical data; Case-Control Studies; Child; Female; Humans; Male; Middle Aged; Neurosurgical Procedures - adverse effects; Neurosurgical Procedures - methods; Randomized Controlled Trials as Topic; Systematic Review and Meta-Analysis; Tranexamic Acid - administration & dosage; Tranexamic Acid - therapeutic use
• ISSN: 0025-7974; 1536-5964; 1536-5964
• DOI: 10.1097/MD.0000000000024678

This study aimed to explore the role of tranexamic acid (TXA) in blood loss control and blood transfusion management of patients undergoing multilevel spine surgery. In this meta-analysis, a comprehensive search of literatures was performed from PubMed, Embase, Cochrane Library, and Web of Science from inception to June 23rd, 2020. Weighed mean difference (WMD) was used as the effect size for measurement data, and risk ratio for enumeration data. Publication bias was assessed by Begg test. Totally 23 studies (11 randomized controlled trials and 12 cohort studies) involving 1621 participants were enrolled in this meta-analysis. The results showed that the administration of TXA can significantly decrease the intraoperative [WMD: -215.655, 95%CI: (-307.462, -123.847), P