Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis

Purpose It is controversial whether a higher intake of n-3 long-chain polyunsaturated fatty acids (n-3 LC PUFA) through breastfeeding is associated or not to a lower blood pressure (BP) during childhood. We aimed to clarify this point by undertaking a meta-analysis involving the data from seven Euro...

Full description

Saved in:
Bibliographic Details
Published in:European journal of nutrition 2021-03, Vol.60 (2), p.989-998
Main Authors: van Rossem, Lenie, Smit, Henriette A., Armand, Martine, Bernard, Jonathan Y., Bisgaard, Hans, Bønnelykke, Klaus, Bruun, Signe, Heude, Barbara, Husby, Steffen, Kyhl, Henriette B., Michaelsen, Kim F., Stark, Ken D., Thijs, Carel, Vinding, Rebecca K., Wijga, Alet H., Lauritzen, Lotte
Format: Article
Language:English
Subjects:
Age
Baby foods
Blood pressure
Breast feeding
Breast milk
Breastfeeding & lactation
Chemistry
Chemistry and Materials Science
Children
Docosahexaenoic acid
Fatty acids
Food and Nutrition
Life Sciences
Meta-analysis
Nutrition
Original Contribution
Polyunsaturated fatty acids
Regression analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose It is controversial whether a higher intake of n-3 long-chain polyunsaturated fatty acids (n-3 LC PUFA) through breastfeeding is associated or not to a lower blood pressure (BP) during childhood. We aimed to clarify this point by undertaking a meta-analysis involving the data from seven European birth cohorts. Methods We searched https://www.birthcohort.net for studies that had collected breast milk samples, and had at least one BP measurement in childhood. Principal investigators were contacted, and all agreed to share data. One additional study was identified by contacts with the principal investigators. For each cohort, we analyzed the association of breast milk n-3 LC PUFAs with systolic and diastolic BP with linear mixed effects models or linear regression, and pooled the estimates with a random effects model. We also investigated age-specific and sex-specific associations. Results A total of 2188 participants from 7 cohorts were included. Overall, no associations between breast milk n-3 LC PUFAs and BP were observed. In the pooled analysis, each 0.1 wt% increment in breast milk docosahexaenoic acid (DHA) was associated with a 1.19 (95% CI − 3.31, 0.94) mmHg lower systolic BP. Associations were similar for boys and girls and at different ages. Conclusion In this individual participant meta-analysis, we found no evidence for an association between breast milk n-3 LC PUFAs and BP.
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-020-02310-4