Depot medroxyprogesterone acetate and norethisterone enanthate differentially impact T‐cell responses and expression of immunosuppressive markers

Problem Injectable contraceptive use may impact immune cell responsiveness and susceptibility to infection. We measured responsiveness of T‐cells from women before and after initiating depot medroxyprogesterone acetate (DMPA) or norethisterone enanthate (Net‐En). Method of study Peripheral blood mon...

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Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2020-03, Vol.83 (3), p.e13210-n/a
Main Authors: Matubu, Allen, Hillier, Sharon L., Meyn, Leslie A., Stoner, Kevin A., Mhlanga, Felix, Mbizvo, Mike, Maramba, Aaron, Chirenje, Zvavahera M., Achilles, Sharon L.
Format: Article
Language:English
Subjects:
12-O-Tetradecanoylphorbol-13-acetate
Acetic acid
Adolescent
Adult
Apoptosis
CD4 antigen
CD4-Positive T-Lymphocytes - drug effects
CD4-Positive T-Lymphocytes - immunology
CD8 antigen
CD8-Positive T-Lymphocytes - drug effects
CD8-Positive T-Lymphocytes - immunology
Cell activation
Cell death
Cells, Cultured
Contraceptive Agents, Female - pharmacology
CTLA-4 Antigen - metabolism
CTLA-4 protein
Cytotoxicity
depot medroxyprogesterone acetate
Female
Flow cytometry
Humans
Immunophenotyping
Intrauterine devices
IUD
Leukocytes (mononuclear)
Lymphocyte Activation
Lymphocytes
Medroxyprogesterone acetate
Medroxyprogesterone Acetate - pharmacology
Norethindrone - analogs & derivatives
Norethindrone - pharmacology
norethisterone enanthate cytotoxic T‐lymphocyte associated protein‐4
PD-1 protein
Peripheral blood mononuclear cells
Programmed Cell Death 1 Receptor - metabolism
programmed cell death‐1
Young Adult
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Summary:Problem Injectable contraceptive use may impact immune cell responsiveness and susceptibility to infection. We measured responsiveness of T‐cells from women before and after initiating depot medroxyprogesterone acetate (DMPA) or norethisterone enanthate (Net‐En). Method of study Peripheral blood mononuclear cells collected from women aged 18‐34 years prior to, at steady state, and nadir concentrations after initiating DMPA (n = 30) or Net‐En (n = 36) and from women initiating copper intrauterine device (CU‐IUD; n = 32) were stimulated with phorbol myristate acetate and analyzed using flow cytometry. We evaluated percentage change in T‐cells expressing programmed cell death‐1 (PD‐1) and cytotoxic T‐lymphocyte associated protein‐4 (CTLA‐4). Results Compared to baseline, there were decreased numbers of CD4+CTLA4+ (P 
ISSN:1046-7408
1600-0897
DOI:10.1111/aji.13210