Inhibition of Fatty Acid Binding Protein 4 in Obese Male Mice Adversely Affects Reproductive Parameters

As obesity is increasing worldwide, obese people use various methods to get rid of excess weight. BMS309403 (A drug) is a specific inhibitor of fatty acid binding protein 4. In this study, the effects of the BMS309403 on serum biochemical markers, testis tissue spermatogenesis and apoptotic markers...

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Bibliographic Details
Published in:Journal of reproduction & infertility 2021-01, Vol.22 (1), p.16-22
Main Authors: Balci, Tevfik, Kocabas, Rahim, Cuce, Gokhan, Akoz, Mehmet
Format: Article
Language:English
Subjects:
Androgens
Apoptosis
B-cell lymphoma
Biochemical markers
Biochemical tests
Fatty acid-binding protein
Fatty acids
Globulins
Inhibin
Lymphocytes B
Lymphoma
Males
Markers
Obesity
Oral administration
Original
Parameters
Proteins
Sex hormones
Solvents
Spermatogenesis
Sucrose
Testes
Testosterone
Tissues
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Summary:As obesity is increasing worldwide, obese people use various methods to get rid of excess weight. BMS309403 (A drug) is a specific inhibitor of fatty acid binding protein 4. In this study, the effects of the BMS309403 on serum biochemical markers, testis tissue spermatogenesis and apoptotic markers were investigated in male mice. Balb/c mice (total=56, each group n=14) were divided into control, obese control, obese solvent and obese drug groups. The obese control, obese solvent and obese drug groups were fed on the high sucrose diet to lead to obesity. After the development of obesity, BMS309403 was orally administered to the obese drug group for six weeks. It was performed in testicular tissues (Johnson Score and apoptosis markers) and biochemical tests (total testosterone, sex hormone binding globulin, inhibin-B tests and free androgen index) were used to evaluate reproductive parameters. The p
ISSN:2228-5482
2251-676X
DOI:10.18502/jri.v22i1.4991