The value of melanoma inhibitory activity and LDH with melanoma patients in a Chinese population

Malignant melanoma is a highly malignant tumor originating from the melanocytes of the neural crest, which is prone to metastasis and has a poor prognosis. Previous research demonstrated that melanoma inhibitory activity (MIA) and lactate dehydrogenase (LDH) could serve as serum markers in malignant...

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Bibliographic Details
Published in:Medicine (Baltimore) 2021-02, Vol.100 (8), p.e24840-e24840
Main Authors: Li, Chujun, Liu, Jinfang, Jiang, Lu, Xu, Jun, Ren, Anjing, Lin, Yu, Yao, Gang
Format: Article
Language:English
Subjects:
Aged
Asian People
Biomarkers - blood
Case-Control Studies
China
Enzyme-Linked Immunosorbent Assay
Extracellular Matrix Proteins - blood
Female
Humans
Kaplan-Meier Estimate
L-Lactate Dehydrogenase - blood
Male
Melanoma - blood
Melanoma - genetics
Melanoma - mortality
Melanoma, Cutaneous Malignant
Middle Aged
Neoplasm Proteins - blood
Neoplasm Staging
Observational Study
Retrospective Studies
Skin Neoplasms - blood
Skin Neoplasms - genetics
Skin Neoplasms - mortality
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Summary:Malignant melanoma is a highly malignant tumor originating from the melanocytes of the neural crest, which is prone to metastasis and has a poor prognosis. Previous research demonstrated that melanoma inhibitory activity (MIA) and lactate dehydrogenase (LDH) could serve as serum markers in malignant melanoma and indicate prognosis in the Caucasian race. Researchers suspected that both MIA and LDH could prompt the prognosis of malignant melanoma in the Chinese population. This study aimed to investigate the value of MIA and LDH in the prognosis of acral malignant melanoma.From January 1, 2014, to December 31, 2017, in Jiangsu Province, 44 acral malignant melanoma patients with complete data were chosen from the clinic. The LDH levels were extracted from their clinical data, and MIA levels were measured by enzyme-linked immunosorbent assay method. 8 paired advancing samples before and after metastasis were examined. 22 health donors were matched to the patient group. Receiver operating characteristic (ROC) curves of MIA and LDH were drawn to determine acral malignant melanoma tumorigenesis and metastasis and finally got the cut-off value. Cumulative survival was illustrated with the Kaplan-Meier plot, and factors were compared using the Log-rank test.Compared with age-matched healthy donors, MIA was significantly high in patients (P 
ISSN:0025-7974
1536-5964
1536-5964
DOI:10.1097/MD.0000000000024840