Differential brain activity as a function of social evaluative stress in early adolescence: Brain function and salivary cortisol

Understanding individual differences in neural responses to stressful environments is an important avenue of research throughout development. These differences may be especially critical during adolescence, which is characterized by opportunities for healthy development and increased susceptibility...

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Bibliographic Details
Published in:Development and psychopathology 2020-12, Vol.32 (5), p.1926-1936
Main Authors: Herzberg, Max P., Hunt, Ruskin H., Thomas, Kathleen M., Gunnar, Megan R.
Format: Article
Language:English
Subjects:
Adolescence
Adolescent
Adolescents
Adult
Brain - diagnostic imaging
Child
Child development
Cortex (cingulate)
Cortisol
Environmental conditions
Families & family life
Frontal gyrus
Hormones
Humans
Hydrocortisone
Magnetic Resonance Imaging
Minnesota
Neurobiology
Neuroimaging
Physiology
Psychopathology
Saliva
Scanners
Social interactions
Speaking
Special Section 2: Early Adversity and Development: Contributions from the Field
Speech
Stress
Stress response
Stress, Psychological - diagnostic imaging
Teenagers
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Summary:Understanding individual differences in neural responses to stressful environments is an important avenue of research throughout development. These differences may be especially critical during adolescence, which is characterized by opportunities for healthy development and increased susceptibility to the development of psychopathology. While the neural correlates of the psychosocial stress response have been investigated in adults, these links have not been explored during development. Using a new task, the Minnesota Imaging Stress Test in Children (MISTiC), differences in activation are found in fusiform gyrus, superior frontal gyrus, insula, and anterior cingulate cortex when comparing a stressful math task to a nonstressful math task. The MISTiC task successfully elicits cortisol responses in a similar proportion of adolescents as in behavioral studies while collecting brain imaging data. Cortisol responders and nonresponders did not differ in their perceived stress level or behavioral performance during the task despite differences in neuroendocrine function. Future research will be able to leverage the MISTiC task for many purposes, including probing associations between individual differences in stress responses with environmental conditions, personality differences, and the development of psychopathology.
ISSN:0954-5794
1469-2198
1469-2198
DOI:10.1017/S095457942000125X