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Effect of TRPM8 and TRPA1 Polymorphisms on COPD Predisposition and Lung Function in COPD Patients
Certain transient receptor potential (TRP) channels including and are widely expressed in the respiratory tract and have been shown to be the receptors of cigarette smoke and particulate matter-the main causative factors of chronic obstructive pulmonary disease (COPD). The aim of the study was to in...
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| Published in: | Journal of personalized medicine 2021-02, Vol.11 (2), p.108 |
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| cites | cdi_FETCH-LOGICAL-c409t-22267612584affae1125d0c74a9371778c75cc675912b948214a6348277092903 |
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| container_issue | 2 |
| container_start_page | 108 |
| container_title | Journal of personalized medicine |
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| creator | Naumov, Denis E Kotova, Olesya O Gassan, Dina A Sugaylo, Ivana Y Afanas'eva, Evgeniya Y Sheludko, Elizaveta G Perelman, Juliy M |
| description | Certain transient receptor potential (TRP) channels including
and
are widely expressed in the respiratory tract and have been shown to be the receptors of cigarette smoke and particulate matter-the main causative factors of chronic obstructive pulmonary disease (COPD). The aim of the study was to investigate the effect of
and
polymorphisms on COPD predisposition and lung function in COPD patients. The study enrolled 143 COPD patients and 104 smokers with post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) > 70%. Lung function was measured by spirometry.
and
polymorphisms were genotyped by LATE-PCR. None of the polymorphisms significantly influenced COPD predisposition after correction for covariates and multiple testing. Among COPD patients, the TT genotype of
rs7819749 was significantly associated with higher degree of bronchial obstruction. In addition, we established that carriers of the C allele of
rs11562975 more commonly had post-bronchodilator FEV1 < 60% (OR 3.2, 95%CI (1.14-8.94),
= 0.03) and revealed the effect of
rs959976 and
rs17865682 on bronchodilator response in COPD. Thus, the obtained results suggest possible involvement of
and
in COPD pathogenesis, indicating the necessity to further investigate their functional role in this pathology. |
| doi_str_mv | 10.3390/jpm11020108 |
| format | article |
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and
are widely expressed in the respiratory tract and have been shown to be the receptors of cigarette smoke and particulate matter-the main causative factors of chronic obstructive pulmonary disease (COPD). The aim of the study was to investigate the effect of
and
polymorphisms on COPD predisposition and lung function in COPD patients. The study enrolled 143 COPD patients and 104 smokers with post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) > 70%. Lung function was measured by spirometry.
and
polymorphisms were genotyped by LATE-PCR. None of the polymorphisms significantly influenced COPD predisposition after correction for covariates and multiple testing. Among COPD patients, the TT genotype of
rs7819749 was significantly associated with higher degree of bronchial obstruction. In addition, we established that carriers of the C allele of
rs11562975 more commonly had post-bronchodilator FEV1 < 60% (OR 3.2, 95%CI (1.14-8.94),
= 0.03) and revealed the effect of
rs959976 and
rs17865682 on bronchodilator response in COPD. Thus, the obtained results suggest possible involvement of
and
in COPD pathogenesis, indicating the necessity to further investigate their functional role in this pathology.</description><identifier>ISSN: 2075-4426</identifier><identifier>EISSN: 2075-4426</identifier><identifier>DOI: 10.3390/jpm11020108</identifier><identifier>PMID: 33567636</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Chronic obstructive pulmonary disease ; Cigarette smoke ; Cigarettes ; Genotype & phenotype ; Lung diseases ; Mortality ; Obstructive lung disease ; Particulate matter ; Pathogenesis ; Pathology ; Physiology ; Polymorphism ; Precision medicine ; Respiration ; Respiratory function ; Respiratory tract ; Smoking ; Statistical analysis ; Thermal cycling ; Transient receptor potential proteins</subject><ispartof>Journal of personalized medicine, 2021-02, Vol.11 (2), p.108</ispartof><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-22267612584affae1125d0c74a9371778c75cc675912b948214a6348277092903</citedby><cites>FETCH-LOGICAL-c409t-22267612584affae1125d0c74a9371778c75cc675912b948214a6348277092903</cites><orcidid>0000-0002-9411-7474 ; 0000-0002-1984-2596 ; 0000-0003-3921-8755</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2489038728/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2489038728?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25733,27903,27904,36991,36992,44569,53769,53771,74872</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33567636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naumov, Denis E</creatorcontrib><creatorcontrib>Kotova, Olesya O</creatorcontrib><creatorcontrib>Gassan, Dina A</creatorcontrib><creatorcontrib>Sugaylo, Ivana Y</creatorcontrib><creatorcontrib>Afanas'eva, Evgeniya Y</creatorcontrib><creatorcontrib>Sheludko, Elizaveta G</creatorcontrib><creatorcontrib>Perelman, Juliy M</creatorcontrib><title>Effect of TRPM8 and TRPA1 Polymorphisms on COPD Predisposition and Lung Function in COPD Patients</title><title>Journal of personalized medicine</title><addtitle>J Pers Med</addtitle><description>Certain transient receptor potential (TRP) channels including
and
are widely expressed in the respiratory tract and have been shown to be the receptors of cigarette smoke and particulate matter-the main causative factors of chronic obstructive pulmonary disease (COPD). The aim of the study was to investigate the effect of
and
polymorphisms on COPD predisposition and lung function in COPD patients. The study enrolled 143 COPD patients and 104 smokers with post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) > 70%. Lung function was measured by spirometry.
and
polymorphisms were genotyped by LATE-PCR. None of the polymorphisms significantly influenced COPD predisposition after correction for covariates and multiple testing. Among COPD patients, the TT genotype of
rs7819749 was significantly associated with higher degree of bronchial obstruction. In addition, we established that carriers of the C allele of
rs11562975 more commonly had post-bronchodilator FEV1 < 60% (OR 3.2, 95%CI (1.14-8.94),
= 0.03) and revealed the effect of
rs959976 and
rs17865682 on bronchodilator response in COPD. Thus, the obtained results suggest possible involvement of
and
in COPD pathogenesis, indicating the necessity to further investigate their functional role in this pathology.</description><subject>Chronic obstructive pulmonary disease</subject><subject>Cigarette smoke</subject><subject>Cigarettes</subject><subject>Genotype & phenotype</subject><subject>Lung diseases</subject><subject>Mortality</subject><subject>Obstructive lung disease</subject><subject>Particulate matter</subject><subject>Pathogenesis</subject><subject>Pathology</subject><subject>Physiology</subject><subject>Polymorphism</subject><subject>Precision medicine</subject><subject>Respiration</subject><subject>Respiratory function</subject><subject>Respiratory tract</subject><subject>Smoking</subject><subject>Statistical analysis</subject><subject>Thermal cycling</subject><subject>Transient receptor potential proteins</subject><issn>2075-4426</issn><issn>2075-4426</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkc9LwzAcxYMobsydvEvBiyDT_GqSXoQxNxUmDpnnkGXpltE2NWkF_3sznWOay_fxzYeXFx4A5wjeEJLB201dIgQxRFAcgS6GPB1Qitnxge6AfggbGI9IMWbwFHQISRlnhHWBGue50U3i8mT-OnsWiaqWWzVEycwVn6Xz9dqGMiSuSkYvs_tk5s3ShtoF29i42-LTtlolk7bS3xv7C6rGmqoJZ-AkV0Uw_d3sgbfJeD56HExfHp5Gw-lAU5g1AxyjcYZwKqjKc2VQlEuoOVUZ4YhzoXmqNeNphvAiowIjqhiJk3OY4QySHrj78a3bRWmWOr7tVSFrb0vlP6VTVv69qexartyH5BlKEaHR4Gpn4N17a0IjSxu0KQpVGdcGiakQKacMkohe_kM3rvVV_N6WimEExyJS1z-U9i4Eb_J9GATltj150F6kLw7z79nfrsgXm3eRiw</recordid><startdate>20210208</startdate><enddate>20210208</enddate><creator>Naumov, Denis E</creator><creator>Kotova, Olesya O</creator><creator>Gassan, Dina A</creator><creator>Sugaylo, Ivana Y</creator><creator>Afanas'eva, Evgeniya Y</creator><creator>Sheludko, Elizaveta G</creator><creator>Perelman, Juliy M</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9411-7474</orcidid><orcidid>https://orcid.org/0000-0002-1984-2596</orcidid><orcidid>https://orcid.org/0000-0003-3921-8755</orcidid></search><sort><creationdate>20210208</creationdate><title>Effect of TRPM8 and TRPA1 Polymorphisms on COPD Predisposition and Lung Function in COPD Patients</title><author>Naumov, Denis E ; 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and
are widely expressed in the respiratory tract and have been shown to be the receptors of cigarette smoke and particulate matter-the main causative factors of chronic obstructive pulmonary disease (COPD). The aim of the study was to investigate the effect of
and
polymorphisms on COPD predisposition and lung function in COPD patients. The study enrolled 143 COPD patients and 104 smokers with post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) > 70%. Lung function was measured by spirometry.
and
polymorphisms were genotyped by LATE-PCR. None of the polymorphisms significantly influenced COPD predisposition after correction for covariates and multiple testing. Among COPD patients, the TT genotype of
rs7819749 was significantly associated with higher degree of bronchial obstruction. In addition, we established that carriers of the C allele of
rs11562975 more commonly had post-bronchodilator FEV1 < 60% (OR 3.2, 95%CI (1.14-8.94),
= 0.03) and revealed the effect of
rs959976 and
rs17865682 on bronchodilator response in COPD. Thus, the obtained results suggest possible involvement of
and
in COPD pathogenesis, indicating the necessity to further investigate their functional role in this pathology.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33567636</pmid><doi>10.3390/jpm11020108</doi><orcidid>https://orcid.org/0000-0002-9411-7474</orcidid><orcidid>https://orcid.org/0000-0002-1984-2596</orcidid><orcidid>https://orcid.org/0000-0003-3921-8755</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of personalized medicine, 2021-02, Vol.11 (2), p.108 |
| issn | 2075-4426 2075-4426 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7915134 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | Chronic obstructive pulmonary disease Cigarette smoke Cigarettes Genotype & phenotype Lung diseases Mortality Obstructive lung disease Particulate matter Pathogenesis Pathology Physiology Polymorphism Precision medicine Respiration Respiratory function Respiratory tract Smoking Statistical analysis Thermal cycling Transient receptor potential proteins |
| title | Effect of TRPM8 and TRPA1 Polymorphisms on COPD Predisposition and Lung Function in COPD Patients |
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