18F-FDG PET/CT Cannot Substitute Endoscopy in the Staging of Gastrointestinal Involvement in Mantle Cell Lymphoma. A Retrospective Multi-Center Cohort Analysis

The detection of gastrointestinal (GI) involvement in Mantle Cell Lymphoma is often underestimated and may have an impact on outcome and clinical management. We aimed to evaluate whether baseline 18F-FDG PET/CT presents comparable results to endoscopic biopsy in the diagnosis of GI localizations. In...

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Published in:Journal of personalized medicine 2021-02, Vol.11 (2), p.123
Main Authors: Skrypets, Tetiana, Ferrari, Cristina, Nassi, Luca, Margiotta Casaluci, Gloria, Puccini, Benedetta, Mannelli, Lara, Filonenko, Kateryna, Kryachok, Irina, Clemente, Felice, Vegliante, Maria Carmela, Daniele, Antonella, Sacchetti, Gianmauro, Guarini, Attilio, Minoia, Carla
Format: Article
Language:English
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Summary:The detection of gastrointestinal (GI) involvement in Mantle Cell Lymphoma is often underestimated and may have an impact on outcome and clinical management. We aimed to evaluate whether baseline 18F-FDG PET/CT presents comparable results to endoscopic biopsy in the diagnosis of GI localizations. In our retrospective cohort of 79 patients, sensitivity and specificity of 18F-FDG PET/CT were low for the stomach, with a fair concordance ( = 0.32), while higher concordance with pathologic results ( = 0.65) was detected in the colorectal tract. Thus, gastric biopsy remains helpful in the staging of MCL despite 18F-FDG PET/CT, while colonoscopy could be omitted in asymptomatic patients. The validation of our data in prospective cohorts is desirable.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm11020123