Research progress of natural compounds in anti-liver fibrosis by affecting autophagy of hepatic stellate cells

Chronic liver diseases caused by various pathogenesis are marked by inflammatory infiltration and wound healing reaction, while their normal regeneration ability is impaired. The unbalance between the generation and the degradation of extracellular matrix (ECM) leads to collagen accumulation and dev...

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Bibliographic Details
Published in:Molecular biology reports 2021-02, Vol.48 (2), p.1915-1924
Main Authors: Shu, Yongxiang, Liu, Xuyou, Huang, Haifeng, Wen, Qi, Shu, Jianchang
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Antioxidants
Apoptosis
Autophagy
Biodegradation
Biomedical and Life Sciences
Collagen
Extracellular matrix
Fibrosis
Hepatocytes
Histology
Inflammation
Kupffer cells
Life Sciences
Liver
Liver diseases
Mini Review
Mini Review Article
Morphology
Organelles
Oxidative stress
Pathogenesis
Phagocytosis
Reactive oxygen species
Stellate cells
Wound healing
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Summary:Chronic liver diseases caused by various pathogenesis are marked by inflammatory infiltration and wound healing reaction, while their normal regeneration ability is impaired. The unbalance between the generation and the degradation of extracellular matrix (ECM) leads to collagen accumulation and develops into liver fibrosis. Inflammation, oxidative stress, and autophagy interact closely in the pathogenesis of hepatic fibrosis. Reactive Oxygen Species (ROS) can not only stimulate Kupffer cells to release massive inflammatory factors, but induce autophagy. However, the latter may suppress inflammatory reaction by inhibiting proinflammatory complex formation directly, and removing damaged organelles or pathogenic microorganism indirectly. At present, effective anti-fibrosis drugs are still lacking. Previous studies have found various natural compounds enabled liver protection through anti-inflammatory, antioxidant, and other mechanisms. In recent years, autophagy, a vital life activity, has been found to be involved in the mechanism of liver fibrosis. As a new target, developing anti-liver fibrosis drugs that regulate the activity of autophagy is very promising. In this review, we summarize the latest studies about natural compounds in the treatment of liver fibrosis by regulating autophagy.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-021-06171-w