Syndrome of inappropriate antidiuretic hormone secretion induced by suvorexant: a case report

Syndrome of inappropriate antidiuretic hormone release (SIADH) can sometimes be caused by an adverse effect of certain psychotropic drugs. However, suvorexant has never been reported to cause SIADH. A 77-year-old man with type 2 diabetes was admitted to the Jichi Medical University Hospital for the...

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Bibliographic Details
Published in:Journal of clinical sleep medicine 2021-03, Vol.17 (3), p.593-594
Main Authors: Takano, Manabu, Okada, Tsuyoshi, Kobayashi, Toshiyuki, Suda, Shiro
Format: Article
Language:English
Subjects:
Aged
Azepines
Case Reports
Diabetes Mellitus, Type 2
Humans
Inappropriate ADH Syndrome
Male
Triazoles
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Summary:Syndrome of inappropriate antidiuretic hormone release (SIADH) can sometimes be caused by an adverse effect of certain psychotropic drugs. However, suvorexant has never been reported to cause SIADH. A 77-year-old man with type 2 diabetes was admitted to the Jichi Medical University Hospital for the treatment of major depression. During the treatment, he was prescribed suvorexant for insomnia. Twelve days after the initiation of suvorexant, he developed hyponatremia, which met the diagnostic criteria of SIADH. We suspected the hyponatremia to be an adverse drug effect of suvorexant because no other cause for SIADH was detected. Accordingly, suvorexant was discontinued 15 days after the onset of SIADH, and hyponatremia improved in 6 days. Although suvorexant has fewer adverse drug reactions and is considered relatively safe, clinicians should be aware of the possibility of SIADH induced by suvorexant.
ISSN:1550-9389
1550-9397
DOI:10.5664/jcsm.8970