Susceptibility and Attenuated Transmissibility of SARS-CoV-2 in Domestic Cats

Abstract Domestic cats, an important companion animal, can be infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This has aroused concern regarding the ability of domestic cats to spread the virus that causes coronavirus disease 2019. We systematically demonstrated the patho...

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Bibliographic Details
Published in:The Journal of Infectious Diseases 2021-04, Vol.223 (8), p.1313-1321
Main Authors: Bao, Linlin, Song, Zhiqi, Xue, Jing, Gao, Hong, Liu, Jiangning, Wang, Jie, Guo, Qian, Zhao, Binbin, Qu, Yajin, Qi, Feifei, Gong, Shuran, Liu, Mingya, Lv, Qi, Li, Dan, Han, Yunlin, Zhao, Wenjie, Deng, Shoulong, Liu, Yunpeng, Xiang, Zhiguang, Yang, Bochao, Deng, Wei, Yu, Haisheng, Cong, Zhe, Wei, Qiang, Xu, Jianguo, Gao, George F, Qin, Chuan
Format: Article
Language:English
Subjects:
ACE2
Amino Acids - metabolism
Angiotensin
Angiotensin-converting enzyme 2
Angiotensin-Converting Enzyme 2 - metabolism
Animals
Cats
Cell Line
Chlorocebus aethiops
Coronaviruses
COVID-19
COVID-19 - metabolism
COVID-19 - transmission
COVID-19 - veterinary
Domestic animals
Female
Humans
Major
Male
Peptidyl-dipeptidase A
SARS-CoV-2 - pathogenicity
Severe acute respiratory syndrome coronavirus 2
Vero Cells
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Summary:Abstract Domestic cats, an important companion animal, can be infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This has aroused concern regarding the ability of domestic cats to spread the virus that causes coronavirus disease 2019. We systematically demonstrated the pathogenesis and transmissibility of SARS-CoV-2 in cats. Serial passaging of the virus between cats dramatically attenuated the viral transmissibility, likely owing to variations of the amino acids in the receptor-binding domain sites of angiotensin-converting enzyme 2 between humans and cats. These findings provide insight into the transmissibility of SARS-CoV-2 in cats and information for protecting the health of humans and cats. Domestic cats are susceptible to SARS-CoV-2 and have attenuated transmissibility after serial passaging.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiab104