Utilizing left atrial strain to identify patients at risk for atrial fibrillation on ibrutinib

Background Ibrutinib is associated with atrial fibrillation (AF), though echocardiographic predictors of AF have not been studied in this population. We sought to determine whether left atrial (LA) strain on transthoracic echocardiography could identify patients at risk for developing ibrutinib‐rela...

Full description

Saved in:
Bibliographic Details
Published in:Echocardiography (Mount Kisco, N.Y.) N.Y.), 2021-01, Vol.38 (1), p.81-88
Main Authors: Singh, Arushi, El Hangouche, Nadia, McGee, Katherine, Gong, Fei‐Fei, Lentz, Robert, Feinglass, Joseph, Akhter, Nausheen
Format: Article
Language:English
Subjects:
Adenine - analogs & derivatives
Atrial Fibrillation
B‐cell malignancies
echocardiography
Heart Atria - diagnostic imaging
Humans
ibrutinib
left atrial strain
Piperidines
Retrospective Studies
Risk Assessment
tyrosine kinase inhibitor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Ibrutinib is associated with atrial fibrillation (AF), though echocardiographic predictors of AF have not been studied in this population. We sought to determine whether left atrial (LA) strain on transthoracic echocardiography could identify patients at risk for developing ibrutinib‐related atrial fibrillation (IRAF). Methods We performed a retrospective review of 66 patients who had an echocardiogram prior to ibrutinib treatment. LA strain was measured with TOMTEC Imaging Systems, obtaining peak atrial longitudinal strain (PALS) and peak atrial contraction strain (PACS) on 4‐chamber and 2‐chamber views. Statistical analysis was performed with chi‐square analysis, t test, or binomial regression analysis, with a P‐value 
ISSN:0742-2822
1540-8175
DOI:10.1111/echo.14946