Predicting Hemolytic Uremic Syndrome and Renal Replacement Therapy in Shiga Toxin–producing Escherichia coli–infected Children

Abstract Background Shiga toxin–producing Escherichia coli (STEC) infections are leading causes of pediatric acute renal failure. Identifying hemolytic uremic syndrome (HUS) risk factors is needed to guide care. Methods We conducted a multicenter, historical cohort study to identify features associa...

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Bibliographic Details
Published in:Clinical infectious diseases 2020-04, Vol.70 (8), p.1643-1651
Main Authors: McKee, Ryan S, Schnadower, David, Tarr, Phillip I, Xie, Jianling, Finkelstein, Yaron, Desai, Neil, Lane, Roni D, Bergmann, Kelly R, Kaplan, Ron L, Hariharan, Selena, Cruz, Andrea T, Cohen, Daniel M, Dixon, Andrew, Ramgopal, Sriram, Rominger, Annie, Powell, Elizabeth C, Kilgar, Jennifer, Michelson, Kenneth A, Beer, Darcy, Bitzan, Martin, Pruitt, Christopher M, Yen, Kenneth, Meckler, Garth D, Plint, Amy C, Bradin, Stuart, Abramo, Thomas J, Gouin, Serge, Kam, April J, Schuh, Abigail, Balamuth, Fran, Hunley, Tracy E, Kanegaye, John T, Jones, Nicholas E, Avva, Usha, Porter, Robert, Fein, Daniel M, Louie, Jeffrey P, Freedman, Stephen B
Format: Article
Language:English
Subjects:
Adolescent
and Commentaries
Child
Cohort Studies
Diarrhea - epidemiology
Escherichia coli Infections - epidemiology
Female
Hemolytic-Uremic Syndrome - epidemiology
Hemolytic-Uremic Syndrome - therapy
Humans
Renal Replacement Therapy
Shiga-Toxigenic Escherichia coli
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Summary:Abstract Background Shiga toxin–producing Escherichia coli (STEC) infections are leading causes of pediatric acute renal failure. Identifying hemolytic uremic syndrome (HUS) risk factors is needed to guide care. Methods We conducted a multicenter, historical cohort study to identify features associated with development of HUS (primary outcome) and need for renal replacement therapy (RRT) (secondary outcome) in STEC-infected children without HUS at initial presentation. Children aged
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciz432