Is Human Papilloma Virus Infection Linked to Periodontitis? A Narrative Review

Purpose of Review Research suggests that periodontal tissue might serve as a reservoir for oral human papillomavirus (HPV) infection, while another hypothesis is that chronic inflammation of the tissue might perpetuate an infection with oral HPV infection. In this narrative review, we summarize the...

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Bibliographic Details
Published in:Current oral health reports 2019-03, Vol.6 (1), p.22-30
Main Authors: Ortiz, Ana P., Ramos-Cartagena, Jeslie M., García-Camacho, Sandra I., Andriankaja, Oelisoa M., Pérez, Cynthia M.
Format: Article
Language:English
Subjects:
Alcohol use
Bacteria
Biopsy
Cancer
Cross-sectional studies
Cytomegalovirus
Ethnicity
Flow cytometry
Gum disease
Head & neck cancer
Human papillomavirus
Hypotheses
Infections
Inflammation
Medicine
Medicine & Public Health
Oral and Maxillofacial Surgery
Pathogens
Risk factors
Scandals
Section Editor
Smoking
Systemic Diseases (N Buduneli
Teeth
Throat cancer
Tongue
Topical Collection on Systemic Diseases
Tumors
Viruses
Womens health
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Summary:Purpose of Review Research suggests that periodontal tissue might serve as a reservoir for oral human papillomavirus (HPV) infection, while another hypothesis is that chronic inflammation of the tissue might perpetuate an infection with oral HPV infection. In this narrative review, we summarize the evidence related to a potential association between oral HPV infection and periodontitis. Recent Findings Twelve articles were identified, and their key findings summarized. Studies vary in sample size, study population, study design, and methods for assessment of oral HPV and periodontitis. Although results are conflicting and still inconclusive, various studies have found an association between oral HPV infection and periodontitis, which is supported by biological plausibility. Summary Future longitudinal studies should further evaluate this association, using clinical definitions of oral HPV infection and periodontitis, and focusing on high-risk populations for oral HPV infection. Studying this association is important since periodontitis might help identify at-risk individuals for oral HPV infection and potentially HPV-related oropharyngeal cancers.
ISSN:2196-3002
2196-3002
DOI:10.1007/s40496-019-0206-6