Cytochalasins from Xylaria sp. CFL5, an Endophytic Fungus of Cephalotaxus fortunei

Three previously undescribed cytochalasins, named xylariasins A‒C ( 1 ‒ 3 ), together with six known ones ( 4 ‒ 9 ) were isolated from Xylaria sp. CFL5, an endophytic fungus of Cephalotaxus fortunei . The chemical structures of all new compounds were elucidated on the basis of extensive spectroscopi...

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Bibliographic Details
Published in:Natural products and bioprospecting 2021-02, Vol.11 (1), p.87-98
Main Authors: Ma, Kai-Liang, Dong, Shi-Hui, Li, Hang-Ying, Wei, Wen-Jun, Tu, Yong-Qiang, Gao, Kun
Format: Article
Language:English
Subjects:
Binding
Biomedical and Life Sciences
Bioorganic Chemistry
Cephalotaxus
Circular dichroism
Cytotoxicity
Dichroism
Endophytes
Food Science
Fungi
Life Sciences
Mathematical analysis
Medicinal Chemistry
Optical properties
Optical rotation
Original
Original Article
Pharmacology/Toxicology
Plant Biochemistry
Plant Sciences
Toxicity
Xylaria
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Summary:Three previously undescribed cytochalasins, named xylariasins A‒C ( 1 ‒ 3 ), together with six known ones ( 4 ‒ 9 ) were isolated from Xylaria sp. CFL5, an endophytic fungus of Cephalotaxus fortunei . The chemical structures of all new compounds were elucidated on the basis of extensive spectroscopic data analyses and electronic circular dichroism calculation, as well as optical rotation calculation. Biological activities of compounds 1 , 4 ‒ 9 were evaluated, including cytotoxic, LAG3/MHC II binding inhibition and LAG3/FGL1 binding inhibition activities. Compounds 6 and 9 possessed cytotoxicity against AGS cells at 5 μM, with inhibition rates of 94% and 64%, respectively. In addition, all tested isolates, except compound 6 , exhibited obvious inhibitory activity against the interaction of both LAG3/MHC II and LAG3/FGL1. Compounds 1 , 5 , 7 , and 8 inhibited LAG3/MHC II with IC 50 values ranging from 2.37 to 4.74 μM. Meanwhile, the IC 50 values of compounds 1 , 7 , and 8 against LAG3/FGL1 were 11.78, 4.39, and 7.45 μM, respectively. Graphic Abstract
ISSN:2192-2195
2192-2209
DOI:10.1007/s13659-020-00279-5