Atrial Fibrillation as a Predictor of Mortality in High Risk COVID-19 Patients: A Multicentre Study of 171 Patients

Certain patient demographics and biomarkers have been suggested to predict survival in patients infected with COVID-19. However, predictors of outcome in patients who are critically ill are unclear. We performed a multicentre analysis of 171 consecutive patients with confirmed COVID-19 who were admi...

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Published in:Heart, lung & circulation lung & circulation, 2021-08, Vol.30 (8), p.1151-1156
Main Authors: Ip, Randy J., Ali, Abbas, Baloch, Zulfiqar Qutrio, Al-Abcha, Abdullah, Jacob, Chris, Arnautovic, Jelena, Boumegouas, Manel, Do, Steven, Meka, Krishna, Wilcox, Matthew, Ip, John
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Atrial fibrillation
Atrial Fibrillation - epidemiology
Coronavirus
COVID-19
COVID-19 - mortality
Critical Illness
Female
Hospital Mortality
Humans
Male
Middle Aged
Mortality
Original
Retrospective Studies
Risk Factors
SARS-CoV-2
Survival Rate
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Summary:Certain patient demographics and biomarkers have been suggested to predict survival in patients infected with COVID-19. However, predictors of outcome in patients who are critically ill are unclear. We performed a multicentre analysis of 171 consecutive patients with confirmed COVID-19 who were admitted to the intensive care unit (ICU) between 1 March 2020 and 30 April 2020 and were followed until 23 May 2020. Demographic data, past medical history, laboratory values, echocardiographic and telemetry data were analysed. Patient status was classified as either alive or deceased at hospital discharge or the end of follow-up period. Mean patient age was 66±13 and 57% were male. Mortality rate of this ICU cohort at the end of follow-up was 46.2%. A multivariable logistic regression analysis identified the presence or history of atrial fibrillation (Odds Ratio 4.8, p=0.004) as a significant cardiovascular attribute that contributed to increased mortality. Mortality of critically ill COVID-19 patients is high. This study suggests a relationship between atrial fibrillation and increased mortality from COVID-19. Early aggressive treatment patients with high risk characteristics, such as atrial fibrillation could improve clinical outcome.
ISSN:1443-9506
1444-2892
1444-2892
DOI:10.1016/j.hlc.2021.02.010