The Potential of Developing Pan-Coronaviral Antibodies to Spike Peptides in Convalescent COVID-19 Patients

Coronaviruses share conservative spike protein (S) on their enveloped membrane surface, where S1 subunit recognizes and binds the cellular receptor, and the S2 subunit mediates membrane fusion. This similarity raises the question: does coronaviral infection by one create protection to others? Conval...

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Bibliographic Details
Published in:Archivum Immunologiae et Therapiae Experimentalis 2021-12, Vol.69 (1), p.5-5, Article 5
Main Authors: Rabets, Andrii, Bila, Galyna, Grytsko, Roman, Samborskyy, Markian, Rebets, Yuriy, Vari, Sandor G., Pagneux, Quentin, Barras, Alexandre, Boukherroub, Rabah, Szunerits, Sabine, Bilyy, Rostyslav
Format: Article
Language:English
Subjects:
Antibodies
Antibodies, Viral - immunology
Biomedical and Life Sciences
Biomedicine
Convalescence
Coronaviruses
COVID-19
COVID-19 - immunology
Cross Reactions
Cross-reactivity
Engineering Sciences
Enzyme-linked immunosorbent assay
Homology
Humans
Immunogenicity
Immunoglobulin G
Immunology
Infections
Membrane fusion
Middle East respiratory syndrome
Middle East Respiratory Syndrome Coronavirus - immunology
Peptides
Pharmacology/Toxicology
Polyclonal antibodies
Proteins
Respiratory diseases
SARS Virus - immunology
SARS-CoV-2 - immunology
Severe acute respiratory syndrome coronavirus 2
Short Communication
Spike Glycoprotein, Coronavirus - immunology
Spike protein
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Summary:Coronaviruses share conservative spike protein (S) on their enveloped membrane surface, where S1 subunit recognizes and binds the cellular receptor, and the S2 subunit mediates membrane fusion. This similarity raises the question: does coronaviral infection by one create protection to others? Convalescent SARS-CoV-2 (COVID-19) sera were tested for cross reactivity with peptides from Middle East respiratory syndrome coronavirus (MERS-CoV) which shares 74% homology. Our results showed significant cross-reactivity with a peptide of the heptad repeat 2 (HR2) domain of the MERS-CoV spike protein. Sera samples of 47 validated seropositive convalescent COVID-19 patients and 40 sera samples of control patients, collected in pre-COVID time were used to establish cross-bind reactivity with the MERS-CoV peptide. Significantly stronger binding ( p  
ISSN:0004-069X
1661-4917
DOI:10.1007/s00005-021-00607-8