Population‐based study to re‐evaluate optimal lymph node yield in colonic cancer

Background It is well established that lymph node (LN) yield in colonic cancer resection has prognostic significance, although optimal numbers are not clear. Here, LN thresholds associated with both LN positivity and survival were evaluated in a single population‐based data set. Methods Treatment re...

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Bibliographic Details
Published in:British journal of surgery 2017-07, Vol.104 (8), p.1087-1096
Main Authors: Del Paggio, J. C., Peng, Y., Wei, X., Nanji, S., MacDonald, P. H., Krishnan Nair, C., Booth, C. M.
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Aged
Aged, 80 and over
Cancer
Colonic Neoplasms - mortality
Colonic Neoplasms - surgery
Colorectal cancer
Epidemiologic Methods
Female
Health risk assessment
Humans
Lymph Node Excision - mortality
Lymphatic Metastasis
Lymphatic system
Male
Middle Aged
Ontario - epidemiology
Original
Population-based studies
Socioeconomic Factors
Young Adult
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Summary:Background It is well established that lymph node (LN) yield in colonic cancer resection has prognostic significance, although optimal numbers are not clear. Here, LN thresholds associated with both LN positivity and survival were evaluated in a single population‐based data set. Methods Treatment records were linked to the Ontario Cancer Registry to identify a 25 per cent random sample of all patients with stage II/III colonic cancer between 2002 and 2008. Multivariable regression and Cox models evaluated factors associated with LN positivity and cancer‐specific survival (CSS) respectively. Optimal thresholds were obtained using sequential regression analysis. Results On adjusted analysis of 5508 eligible patients, younger age (P 
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.10540