Oral drug delivery systems using core–shell structure additive manufacturing technologies: a proof-of-concept study

Abstract Objectives The aim of this study was to couple fused deposition modelling 3D printing with melt extrusion technology to produce core–shell-structured controlled-release tablets with dual-mechanism drug-release performance in a simulated intestinal fluid medium. Coupling abovementioned techn...

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Bibliographic Details
Published in:Journal of pharmacy and pharmacology 2021-03, Vol.73 (2), p.152-160
Main Authors: Zhang, Jiaxiang, Xu, Pengchong, Vo, Anh Q, Repka, Michael A
Format: Article
Language:English
Subjects:
Acetaminophen - administration & dosage
Acetaminophen - chemistry
Administration, Oral
Delayed-Action Preparations
Drug Delivery Systems
Drug Liberation
Printing, Three-Dimensional
Proof of Concept Study
Research Papers
Solubility
Tablets
Technology, Pharmaceutical - methods
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Summary:Abstract Objectives The aim of this study was to couple fused deposition modelling 3D printing with melt extrusion technology to produce core–shell-structured controlled-release tablets with dual-mechanism drug-release performance in a simulated intestinal fluid medium. Coupling abovementioned technologies for personalized drug delivery can improve access to complex dosage formulations at a reasonable cost. Compared with traditional pharmaceutical manufacturing, this should facilitate the following: (1) the ability to manipulate drug release by adjusting structures, (2) enhanced solubility and bioavailability of poorly water-soluble drugs and (3) on-demand production of more complex structured dosages for personalized treatment. Methods Acetaminophen was the model drug and the extrusion process was evaluated by a series of physicochemical characterizations. The geometries, morphologies, and in vitro drug-release performances were compared between directly compressed and 3D-printed tablets. Key findings Initially, 3D-printed tablets released acetaminophen more rapidly than directly compressed tablets. Drug release became constant and steady after a pre-determined time. Thus, rapid effectiveness was ensured by an initially fast acetaminophen release and an extended therapeutic effect was achieved by stabilizing drug release. Conclusions The favourable drug-release profiles of 3D-printed tablets demonstrated the advantage of coupling HME with 3D printing technology to produce personalized dosage formulations.
ISSN:0022-3573
2042-7158
DOI:10.1093/jpp/rgaa037