Emerging Insights and Interventions for Diabetic Retinopathy

Purpose of Review To introduce recent advances in the understanding of diabetic retinopathy and to summarize current and emerging strategies to treat this common and complex cause of vision loss. Recent Findings Advances in retinal imaging and functional analysis indicate that retinal vascular and n...

Full description

Saved in:
Bibliographic Details
Published in:Current diabetes reports 2019-10, Vol.19 (10), p.100-16, Article 100
Main Authors: Honasoge, Avinash, Nudleman, Eric, Smith, Morton, Rajagopal, Rithwick
Format: Article
Language:English
Subjects:
Animals
Diabetes
Diabetic retinopathy
Diabetic Retinopathy - pathology
Diabetic Retinopathy - physiopathology
Diabetic Retinopathy - therapy
Edema
Growth factors
Humans
Medicine
Medicine & Public Health
Microvascular Complications—Retinopathy (DL Chao and G Yiu
Retina
Retina - pathology
Retina - physiopathology
Risk Assessment
Section Editors
Topical Collection on Microvascular Complications—Retinopathy
Vascular Endothelial Growth Factor A - antagonists & inhibitors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose of Review To introduce recent advances in the understanding of diabetic retinopathy and to summarize current and emerging strategies to treat this common and complex cause of vision loss. Recent Findings Advances in retinal imaging and functional analysis indicate that retinal vascular and neural pathologies exist long before the development of clinically visible retinopathy. Such diagnostics could facilitate risk stratification and selective early intervention in high-risk patients. Antagonists of the vascular endothelial growth factor pathway effectively reduce vision loss in diabetes and promote regression of disease severity. Promising new strategies to treat diabetic retinopathy involve novel systemic diabetes therapy and ocular therapies that antagonize angiogenic growth factor signaling, improve blood-retina barrier function and neurovascular coupling, modulate neuroretinal metabolism, or provide neuroprotection. Summary Long considered a pure microvasculopathy, diabetic retinopathy in fact affects the neural and vascular retina as well as neurovascular communication. Emerging therapies include those that target neuroretinal dysfunction in addition to those modulating vascular biology.
ISSN:1534-4827
1539-0829
DOI:10.1007/s11892-019-1218-2