Role of Inflammation in Virus Pathogenesis during Pregnancy

Viral infections during pregnancy lead to a spectrum of maternal and fetal outcomes, ranging from asymptomatic disease to more critical conditions presenting with severe maternal morbidity, stillbirth, preterm birth, intrauterine growth restriction, and fetal congenital anomalies, either apparent at...

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Bibliographic Details
Published in:Journal of virology 2020-12, Vol.95 (2)
Main Authors: Chudnovets, Anna, Liu, Jin, Narasimhan, Harish, Liu, Yang, Burd, Irina
Format: Article
Language:English
Subjects:
Female
Humans
Infant, Newborn
Inflammation - immunology
Minireview
Placenta - immunology
Placenta - virology
Pregnancy
Pregnancy Complications, Infectious - immunology
Pregnancy Complications, Infectious - pathology
Pregnancy Complications, Infectious - virology
Pregnancy Outcome
Virus Diseases - immunology
Virus Diseases - pathology
Virus Diseases - virology
Viruses - classification
Viruses - immunology
Viruses - pathogenicity
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Summary:Viral infections during pregnancy lead to a spectrum of maternal and fetal outcomes, ranging from asymptomatic disease to more critical conditions presenting with severe maternal morbidity, stillbirth, preterm birth, intrauterine growth restriction, and fetal congenital anomalies, either apparent at birth or later in life. In this article, we review the pathogenesis of several viral infections that are particularly relevant in the context of pregnancy and intrauterine inflammation. Understanding the diverse mechanisms employed by viral pathogens as well as the repertoire of immune responses induced in the mother may help to establish novel therapeutic options to attenuate changes in the maternal-fetal interface and prevent adverse pregnancy outcomes.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.01381-19