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Role of Inflammation in Virus Pathogenesis during Pregnancy

Viral infections during pregnancy lead to a spectrum of maternal and fetal outcomes, ranging from asymptomatic disease to more critical conditions presenting with severe maternal morbidity, stillbirth, preterm birth, intrauterine growth restriction, and fetal congenital anomalies, either apparent at...

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Published in:	Journal of virology 2020-12, Vol.95 (2)
Main Authors:	Chudnovets, Anna, Liu, Jin, Narasimhan, Harish, Liu, Yang, Burd, Irina
Format:	Article
Language:	English
Subjects:	Female Humans Infant, Newborn Inflammation - immunology Minireview Placenta - immunology Placenta - virology Pregnancy Pregnancy Complications, Infectious - immunology Pregnancy Complications, Infectious - pathology Pregnancy Complications, Infectious - virology Pregnancy Outcome Virus Diseases - immunology Virus Diseases - pathology Virus Diseases - virology Viruses - classification Viruses - immunology Viruses - pathogenicity
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container_title	Journal of virology
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creator	Chudnovets, Anna Liu, Jin Narasimhan, Harish Liu, Yang Burd, Irina
description	Viral infections during pregnancy lead to a spectrum of maternal and fetal outcomes, ranging from asymptomatic disease to more critical conditions presenting with severe maternal morbidity, stillbirth, preterm birth, intrauterine growth restriction, and fetal congenital anomalies, either apparent at birth or later in life. In this article, we review the pathogenesis of several viral infections that are particularly relevant in the context of pregnancy and intrauterine inflammation. Understanding the diverse mechanisms employed by viral pathogens as well as the repertoire of immune responses induced in the mother may help to establish novel therapeutic options to attenuate changes in the maternal-fetal interface and prevent adverse pregnancy outcomes.
doi_str_mv	10.1128/JVI.01381-19
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source	American Society for Microbiology; Open Access: PubMed Central
subjects	Female Humans Infant, Newborn Inflammation - immunology Minireview Placenta - immunology Placenta - virology Pregnancy Pregnancy Complications, Infectious - immunology Pregnancy Complications, Infectious - pathology Pregnancy Complications, Infectious - virology Pregnancy Outcome Virus Diseases - immunology Virus Diseases - pathology Virus Diseases - virology Viruses - classification Viruses - immunology Viruses - pathogenicity
title	Role of Inflammation in Virus Pathogenesis during Pregnancy
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