Optic Nerve Head Changes in Patients with Optic Neuritis Secondary to Multiple Sclerosis: A Comparison of the Affected and Fellow Healthy Eyes

• Published in: Medeniyet medical journal 2020, Vol.35 (4), p.330-337
• Main Authors: Balci, Sevcan, Yildiz, Merve Beyza, Ozcelik Kose, Alev, Suer, Devran, Turan Vural, Ece, Emir, Canan, Yenerel, Nursal Melda
• Format: Article
• Language: English
• Subjects: Original Study
• ISSN: 2149-2042; 2149-4606
• DOI: 10.5222/MMJ.2020.99075

To evaluate the thickness of lamina cribrosa (LC) in patients with multiple sclerosis (MS) using optical coherence tomography (OCT) and the effect of optic neuritis (ON) attack on these measurements during the remission period. The study included 20 cases diagnosed with relapsing-remitting MS with a history of ON attacks affecting one eye and in remission of MS and ON attacks for at least three months, and 28 randomly selected eyes of age- and sex-matched healthy controls. In the MS group, the eyes affected by ON attack were assigned as Group 1 (MS+ON), their fellow unaffected eyes as Group 2 (MS-ON), and healthy control eyes as Group 3. The LC, peripapillary retinal nerve fiber layer (ppRNFL), and subfoveal choroidal thickness measurements were made by using OCT in all cases, and results were compared between the groups. The mean LC thickness in MS+ON and MS-ON groups was significantly lower than the control group (p