Effect of 670 nm laser photobiomodulation on vascular density and fibroplasia in late stages of tissue repair

This study aimed to investigate the effects of gallium‐aluminum‐arsenium (GaAlAs) (670 nm) laser therapy on neoangiogenesis and fibroplasia during tissue remodelling. Forty male Wistar rats underwent cutaneous surgery and were divided into 2 experimental groups: the Control and Laser group (9 mW, 67...

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Bibliographic Details
Published in:International wound journal 2018-04, Vol.15 (2), p.274-282
Main Authors: Fortuna, Tila, Gonzalez, Ana Cristina, Sá, Maíra F, Andrade, Zilton de A, Reis, Sílvia R A, Medrado, Alena R A P
Format: Article
Language:English
Subjects:
angiogenesis‐inducing agents
angiogenesis‐modulating agents
laser therapy
low‐level light therapy
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Summary:This study aimed to investigate the effects of gallium‐aluminum‐arsenium (GaAlAs) (670 nm) laser therapy on neoangiogenesis and fibroplasia during tissue remodelling. Forty male Wistar rats underwent cutaneous surgery and were divided into 2 experimental groups: the Control and Laser group (9 mW, 670 nm, 0.031 W/cm2, 4 J/cm2). After 14, 21, 28, and 35 days, the animals were euthanised. Descriptive and quantitative analyses were performed in sections stained with haematoxylin‐eosin and Sirius Red, respectively. The amounts of VEGF+ and CD31+ cells were evaluated by immunohistochemistry and histomorphometric analysis, respectively. Statistical analysis was performed using the Mann‐Whitney, Friedman, and Spearman correlation test, P 
ISSN:1742-4801
1742-481X
DOI:10.1111/iwj.12861