Beneficial effects of Ankaferd Blood Stopper on dermal wound healing: an experimental study

• Published in: International wound journal 2014-02, Vol.11 (1), p.64-68
• Main Authors: Akalin, Cagri, Kuru, Serdar, Barlas, Aziz Mutlu, Kismet, Kemal, Kaptanoglu, Bugra, Demir, Aydin, Astarci, Hesna Muzeyyen, Ustun, Huseyin, Ertas, Ertugrul
• Format: Article
• Language: English
• Subjects: Animals; Ankaferd Blood Stopper; Ankaferd Blood Stopper; Topical haemostatic agents; Wound healing; Collagen Type I - analysis; Collagen Type II - analysis; Contracture - etiology; Male; Medicine, Traditional; Original; Plant Extracts - pharmacology; Rats; Rats, Wistar; Skin - chemistry; Skin - injuries; Skin - pathology; Topical haemostatic agents; Tunisia; Wound healing; Wound Healing - drug effects
• ISSN: 1742-4801; 1742-481X
• DOI: 10.1111/j.1742-481X.2012.01063.x

Ankaferd Blood Stopper® (ABS) is a folkloric medicinal plant extract used as a haemostatic agent in traditional Turkish medicine. The aim of this study was to investigate the efficacy of ABS on the healing of dermal wounds in a rat model. Twenty Wistar albino rats were divided into two groups. Standard full‐thickness skin defects were created on the back of the rats. In the control group (group 1), dressings moisturised with saline were changed daily. In the study group (group 2), the wounds were cleaned daily with saline, Ankaferd solution was applied, then the wounds were covered with moisturised dressings. The contraction percentage of wound areas were calculated on the 3rd, 7th, 10th and 14th days using a planimetric programme. On day 14, the wound areas were excised for histopathological examination, inflammatory scoring and evaluation of collagen deposition. The study group was superior to the control group in terms of inflammatory scoring, type I/type III collagen ratio and wound contraction rates. ABS® may be used effectively and safely on full‐thickness wounds as a natural product.