Potential role of statins on wound healing: review of the literature

Wound healing is a dynamic and complex biological process, which requires coordinated events including haemostasis, inflammation, proliferation, revascularisation and remodelling. Impaired wound healing is a common problem that occurs in both community and hospital settings. Various experimental and...

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Bibliographic Details
Published in:International wound journal 2012-06, Vol.9 (3), p.238-247
Main Authors: Farsaei, Shadi, Khalili, Hossein, Farboud, Effat Sadat
Format: Article
Language:English
Subjects:
Animals
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Invited Review
Statin
Treatment Outcome
Wound healing
Wound Healing - drug effects
Wounds and Injuries - drug therapy
Wounds and Injuries - pathology
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Summary:Wound healing is a dynamic and complex biological process, which requires coordinated events including haemostasis, inflammation, proliferation, revascularisation and remodelling. Impaired wound healing is a common problem that occurs in both community and hospital settings. Various experimental and clinical studies have evaluated different modalities for the treatment of topical wounds, such as sugar, antibiotics, honey and phytotherapies; also statins have diverse pleiotropic effects that have been suggested to be useful to improve wound healing. Data derived from both animal and human studies showed that statins especially atorvastatin, simvastatin and pravastatin can accelerate the wound‐healing process. However, further high‐quality and evidence‐based studies are needed to address the best statin drug, appropriate dose, the best administration route, duration of treatment and to determine correlation between pleiotropic effects of statins and their probable clinical benefits.
ISSN:1742-4801
1742-481X
DOI:10.1111/j.1742-481X.2011.00888.x