Ovarian adenocarcinoma with metastases in a white rhinoceros

A 36-y-old white rhinoceros (Ceratotherium simum) was presented with respiratory distress, sanguineous vaginal exudate, and anorexia. The clinical signs progressed over 40 d, and the rhinoceros died. Autopsy revealed significant ascites; a unilateral, 12.5-cm diameter, polypoid mass in the left ovar...

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Bibliographic Details
Published in:Journal of veterinary diagnostic investigation 2021-03, Vol.33 (2), p.366-369
Main Authors: Kim, Soo-Hyeon, Seung, Byung-Joon, Cho, Seung-Hee, Lim, Ha-Young, Bae, Min-Kyung, Eo, Kyung-Yeon, Yeo, Yong-Gu, Son, Jang-Won, Sur, Jung-Hyang
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adenocarcinoma - pathology
Adenocarcinoma - veterinary
Animals
Brief Reports
Diaphragm - pathology
Female
Lung Neoplasms - diagnosis
Lung Neoplasms - secondary
Lung Neoplasms - veterinary
Muscle Neoplasms - diagnosis
Muscle Neoplasms - secondary
Muscle Neoplasms - veterinary
Neoplasm Metastasis
Ovarian Neoplasms - diagnosis
Ovarian Neoplasms - pathology
Ovarian Neoplasms - veterinary
Perissodactyla
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Summary:A 36-y-old white rhinoceros (Ceratotherium simum) was presented with respiratory distress, sanguineous vaginal exudate, and anorexia. The clinical signs progressed over 40 d, and the rhinoceros died. Autopsy revealed significant ascites; a unilateral, 12.5-cm diameter, polypoid mass in the left ovary; a white, firm transmural mass in the right uterine horn; a white, friable mass in the lung; and white-to-tan, friable small nodules in the diaphragm. Histologic examination revealed similar neoplastic cells in the masses in all 4 locations, composed predominantly of epithelial cells proliferating in a tubulopapillary pattern with significant nuclear atypia and numerous atypical mitotic figures (18–42 per 2.37 mm2). Immunohistochemistry for CK7 (cytokeratin 7) and CK20 (cytokeratin 20) suggest that the ovarian, pulmonary, and diaphragmatic lesions were of ovarian origin and that the ovary was the primary tumor site.
ISSN:1040-6387
1943-4936
DOI:10.1177/1040638720986789