Collagen-Carboxymethylcellulose Biocomposite Wound-Dressings with Antimicrobial Activity

Microbial infections associated with skin diseases are frequently investigated since they impact on the progress of pathology and healing. The present work proposes the development of freeze-dried, glutaraldehyde cross-linked, and non-cross-linked biocomposite dressings with a porous structure, whic...

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Bibliographic Details
Published in:Materials 2021-03, Vol.14 (5), p.1153
Main Authors: Neacsu, Ionela Andreea, Leau, Sorina-Alexandra, Marin, Stefania, Holban, Alina Maria, Vasile, Bogdan-Stefan, Nicoara, Adrian-Ionut, Ene, Vladimir Lucian, Bleotu, Coralia, Albu Kaya, Mădălina Georgiana, Ficai, Anton
Format: Article
Language:English
Subjects:
Absorption spectra
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Aqueous solutions
Biomedical materials
Coliforms
Collagen
Composite materials
Crosslinking
Drug dosages
E coli
Freeze drying
Hydrogels
In vitro methods and tests
Medical equipment
Microorganisms
Microscopy
Morphology
Nanoparticles
Nosocomial infections
Polymers
Porous materials
Silver
Skin
Sodium
Stability analysis
Toxicity
Wound healing
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Summary:Microbial infections associated with skin diseases are frequently investigated since they impact on the progress of pathology and healing. The present work proposes the development of freeze-dried, glutaraldehyde cross-linked, and non-cross-linked biocomposite dressings with a porous structure, which may assist the reepithelization process through the presence of collagen and carboxymethylcellulose, along with a therapeutic antimicrobial effect, due to silver nanoparticles (AgNPs) addition. Phisyco-chemical characterization revealed the porous morphology of the obtained freeze-dried composites, the presence of high crystalline silver nanoparticles with truncated triangular and polyhedral morphologies, as well as the characteristic absorption bands of collagen, silver, and carboxymethylcellulose. In vitro tests also assessed the stability, functionality, and the degradability rate of the obtained wound-dressings. Antimicrobial assay performed on Gram-negative ( ), Gram-positive ( ) bacteria, and yeast ( ) models demonstrated that composite wound dressings based on collagen, carboxymethylcellulose, and AgNPs are suitable for skin lesions because they prevent the risk of infection and have prospective wound healing capacity. Moreover, the cell toxicity studies proved that the obtained materials can be used in long time treatments, with no cytotoxic effects.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma14051153