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Validation of Normal P-Wave Parameters in a Large Unselected Pediatric Population of North-Western Romania: Results of the CARDIOPED Project

Aims. Reference values of the P-wave on 12 lead electrocardiograms are lacking for children and adolescents in Eastern Europe. Hence, the present study is aimed at determining the standard values of the P-wave in children and adolescents based on ECG data from the CARDIOPED project, a large-scale ge...

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Published in:	Disease markers 2021, Vol.2021, p.6657982-5
Main Authors:	Cismaru, Gabriel, Lazea, Cecilia, Mureşan, Lucian, Gusetu, Gabriel, Rosu, Radu, Pop, Dana, Zdrenghea, Dumitru, Farcaş, Anca Daniela, Căinap, Simona Sorana
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Subjects:	Adolescent Adolescents Age Child Children EKG Electrocardiography Electrocardiography - methods Electrocardiography - standards Female Heart rate Humans Male P waves Parents & parenting Pediatrics Population Reference Values Schools Screening Statistical analysis
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description	Aims. Reference values of the P-wave on 12 lead electrocardiograms are lacking for children and adolescents in Eastern Europe. Hence, the present study is aimed at determining the standard values of the P-wave in children and adolescents based on ECG data from the CARDIOPED project, a large-scale general population of children who participated in a screening program in Transylvania, Romania. Methods and Results. A total of 22,411 ECGs of participants aged 6 to 18 years old from a school-based ECG screening were obtained between February 2015 and December 2015 in Transylvania, Romania. Three pediatric cardiologists manually reviewed each ECG. P-wave duration, voltage, axis, and correlation with gender and age were analyzed. The mean P-wave duration was 88±10.7 ms, with a maximum duration of 128 ms. P-wave showed a positive correlation with age but did not differ between sexes. There was a positive correlation between the P-wave duration and the heart rate, but not with the body max index. The mean P-wave axis was 40.4±31.1, and the mean P-wave amplitude was 0.12±0.03 mV. Conclusion. In this study on many pediatric subjects, we have provided normal limits for the P-wave in Romanian children aged 6-18 years. Our findings are useful for creating interpretation guidelines for pediatric ECG.
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Reference values of the P-wave on 12 lead electrocardiograms are lacking for children and adolescents in Eastern Europe. Hence, the present study is aimed at determining the standard values of the P-wave in children and adolescents based on ECG data from the CARDIOPED project, a large-scale general population of children who participated in a screening program in Transylvania, Romania. Methods and Results. A total of 22,411 ECGs of participants aged 6 to 18 years old from a school-based ECG screening were obtained between February 2015 and December 2015 in Transylvania, Romania. Three pediatric cardiologists manually reviewed each ECG. P-wave duration, voltage, axis, and correlation with gender and age were analyzed. The mean P-wave duration was 88±10.7 ms, with a maximum duration of 128 ms. P-wave showed a positive correlation with age but did not differ between sexes. There was a positive correlation between the P-wave duration and the heart rate, but not with the body max index. The mean P-wave axis was 40.4±31.1, and the mean P-wave amplitude was 0.12±0.03 mV. Conclusion. In this study on many pediatric subjects, we have provided normal limits for the P-wave in Romanian children aged 6-18 years. Our findings are useful for creating interpretation guidelines for pediatric ECG.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2021/6657982</identifier><identifier>PMID: 33747254</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Adolescent ; Adolescents ; Age ; Child ; Children ; EKG ; Electrocardiography ; Electrocardiography - methods ; Electrocardiography - standards ; Female ; Heart rate ; Humans ; Male ; P waves ; Parents & parenting ; Pediatrics ; Population ; Reference Values ; Schools ; Screening ; Statistical analysis</subject><ispartof>Disease markers, 2021, Vol.2021, p.6657982-5</ispartof><rights>Copyright © 2021 Gabriel Cismaru et al.</rights><rights>Copyright © 2021 Gabriel Cismaru et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 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Reference values of the P-wave on 12 lead electrocardiograms are lacking for children and adolescents in Eastern Europe. Hence, the present study is aimed at determining the standard values of the P-wave in children and adolescents based on ECG data from the CARDIOPED project, a large-scale general population of children who participated in a screening program in Transylvania, Romania. Methods and Results. A total of 22,411 ECGs of participants aged 6 to 18 years old from a school-based ECG screening were obtained between February 2015 and December 2015 in Transylvania, Romania. Three pediatric cardiologists manually reviewed each ECG. P-wave duration, voltage, axis, and correlation with gender and age were analyzed. The mean P-wave duration was 88±10.7 ms, with a maximum duration of 128 ms. P-wave showed a positive correlation with age but did not differ between sexes. There was a positive correlation between the P-wave duration and the heart rate, but not with the body max index. 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subjects	Adolescent Adolescents Age Child Children EKG Electrocardiography Electrocardiography - methods Electrocardiography - standards Female Heart rate Humans Male P waves Parents & parenting Pediatrics Population Reference Values Schools Screening Statistical analysis
title	Validation of Normal P-Wave Parameters in a Large Unselected Pediatric Population of North-Western Romania: Results of the CARDIOPED Project
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