Evaluation of Subependymal Gray Matter Heterotopias on Fetal MRI

• Published in: American journal of neuroradiology : AJNR 2016-04, Vol.37 (4), p.720-725
• Main Authors: Nagaraj, U D, Peiro, J L, Bierbrauer, K S, Kline-Fath, B M
• Format: Article
• Language: English
• Subjects: Adult; Arnold-Chiari Malformation - diagnostic imaging; Arnold-Chiari Malformation - pathology; Brain - diagnostic imaging; Brain - pathology; Cerebral Ventricles - diagnostic imaging; Cerebral Ventricles - pathology; Cohort Studies; Ependyma - diagnostic imaging; Ependyma - pathology; Female; Fetus - diagnostic imaging; Fetus - pathology; Gray Matter - diagnostic imaging; Gray Matter - pathology; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Pediatrics; Pregnancy; Retrospective Studies; Spinal Dysraphism - diagnostic imaging; Spinal Dysraphism - pathology; Ultrasonography, Prenatal
• ISSN: 0195-6108; 1936-959X; 1936-959X
• DOI: 10.3174/ajnr.A4585

Subependymal grey matter heterotopias are seen in a high proportion of children with Chiari II malformation and are potentially clinically relevant. However, despite its growing use, there is little in the literature describing its detection on fetal MRI. Our aim was to evaluate the accuracy in diagnosing subependymal gray matter heterotopias in fetuses with spinal dysraphism on fetal MR imaging. This study is a retrospective analysis of 203 fetal MRIs performed at a single institution for spinal dysraphism during a 10-year period. Corresponding obstetric sonography, postnatal imaging, and clinical/operative reports were reviewed. Of the fetal MRIs reviewed, 95 fetuses were included in our analysis; 23.2% (22/95) were suspected of having subependymal gray matter heterotopias on fetal MR imaging prospectively. However, only 50% (11/22) of these cases were confirmed on postnatal brain MR imaging. On postnatal brain MR imaging, 28.4% (27/95) demonstrated imaging findings consistent with subependymal gray matter heterotopia. Only 40.7% (11/27) of these cases were prospectively diagnosed on fetal MR imaging. Fetal MR imaging is limited in its ability to identify subependymal gray matter heterotopias in fetuses with spinal dysraphism. It is believed that this limitation relates to a combination of factors, including artifacts from fetal motion, the very small size of fetal neuroanatomy, differences in imaging techniques, and, possibly, irregularity related to denudation of the ependyma/subependyma in the presence of spinal dysraphism and/or stretching of the germinal matrix in ventriculomegaly.