Different Functional and Microstructural Changes Depending on Duration of Mild Cognitive Impairment in Parkinson Disease

The higher cortical burden of Lewy body and Alzheimer disease-type pathology has been reported to be associated with a faster onset of cognitive impairment of Parkinson disease. So far, there has been a few studies only about the changes of gray matter volume depending on duration of cognitive impai...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2016-05, Vol.37 (5), p.897-903
Main Authors: Shin, N-Y, Shin, Y S, Lee, P H, Yoon, U, Han, S, Kim, D J, Lee, S-K
Format: Article
Language:English
Subjects:
Adult Brain
Brain - diagnostic imaging
Brain - pathology
Cognitive Dysfunction - diagnostic imaging
Cognitive Dysfunction - etiology
Cognitive Dysfunction - pathology
Female
Functional
Humans
Magnetic Resonance Imaging - methods
Male
Parkinson Disease - complications
Parkinson Disease - diagnostic imaging
Parkinson Disease - pathology
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Summary:The higher cortical burden of Lewy body and Alzheimer disease-type pathology has been reported to be associated with a faster onset of cognitive impairment of Parkinson disease. So far, there has been a few studies only about the changes of gray matter volume depending on duration of cognitive impairment in Parkinson disease. Therefore, our aim was to evaluate the different patterns of structural and functional changes in Parkinson disease with mild cognitive impairment according to the duration of parkinsonism before mild cognitive impairment. Fifty-nine patients with Parkinson disease with mild cognitive impairment were classified into 2 groups on the basis of shorter (
ISSN:0195-6108
1936-959X
DOI:10.3174/ajnr.A4626