Lung neoplasm mimicking as ectopic pregnancy due to paraneoplastic secretion of human chorionic gonadotropin: a case report and literature review

Purpose The present systematic review aimed to examine the relationship between lung neoplasm and human chorionic gonadotropin (HCG). Especially, women with lung neoplasm mimicking as ectopic pregnancy were explored. Methods A rare case of lung neoplasm with high serum β-HCG, which was initially tho...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2021-03, Vol.303 (3), p.607-614
Main Authors: Peng, Jin, lv, Shangge, Liu, Lin, Feng, Shuai, Xing, Naidong
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Case reports
Chorionic Gonadotropin - blood
Chorionic Gonadotropin, beta Subunit, Human - blood
Endocrinology
Female
Glycoproteins
Gynecology
Human Genetics
Humans
Literature reviews
Lung cancer
Lung Neoplasms - blood
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Medicine
Medicine & Public Health
National libraries
Obstetrics
Obstetrics/Perinatology/Midwifery
Pregnancy
Pregnancy complications
Pregnancy, Ectopic - blood
Review
Systematic review
Tumors
Citations: Items that this one cites
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Summary:Purpose The present systematic review aimed to examine the relationship between lung neoplasm and human chorionic gonadotropin (HCG). Especially, women with lung neoplasm mimicking as ectopic pregnancy were explored. Methods A rare case of lung neoplasm with high serum β-HCG, which was initially thought to be ectopic pregnancy, was reported. A literature search was performed of the US National Library of Medicine (MEDLINE), EMBASE, PubMed, and the Cochrane Database of Systematic Reviews using appropriate keywords and subject headings to February 2020. Results Studies assessed lung neoplasm patients with positive HCG were included. Twenty studies, including 24 patients, were included. These cases illustrate the importance of considering the possibility of paraneoplastic secretion of β-HCG in patients who have a positive pregnancy test. This may prevent a delay in the diagnosis and treatment of malignancy in young women. Of the 24 cases, only 7 (29.17%) were managed surgically; others were managed conservatively or with chemotherapy or radiation. Conclusion The present systematic review shows the need to re-awaken awareness and high index of suspicion to lung neoplasm diagnosis in patients with positive pregnancy test.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-020-05927-2