Nanomaterials and the Serosal Immune System in the Thoracic and Peritoneal Cavities

The thoracic and peritoneal cavities are lined by serous membranes and are home of the serosal immune system. This immune system fuses innate and adaptive immunity, to maintain local homeostasis and repair local tissue damage, and to cooperate closely with the mucosal immune system. Innate lymphoid...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2021-03, Vol.22 (5), p.2610
Main Authors: Kuper, C Frieke, Pieters, Raymond H H, van Bilsen, Jolanda H M
Format: Article
Language:English
Subjects:
Abdomen
Adaptive immunity
Adaptive systems
Adipocytes
Adipose tissue
Animals
Bacteria
Diaphragm (Anatomy)
Homeostasis
Homeostasis - immunology
Humans
Immune system
Immune System - immunology
Inflammation
Inflammation - immunology
Lymphatic system
Lymphocytes - immunology
Lymphoid cells
Lymphoid tissue
Mesothelioma
Mucosal immunity
Nanomaterials
Nanostructures - chemistry
Nanotechnology
Peritoneal Cavity - physiology
Peritoneum
Review
Roles
Serous Membrane - immunology
Smooth muscle
Spleen
Thoracic Cavity - immunology
Thorax
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The thoracic and peritoneal cavities are lined by serous membranes and are home of the serosal immune system. This immune system fuses innate and adaptive immunity, to maintain local homeostasis and repair local tissue damage, and to cooperate closely with the mucosal immune system. Innate lymphoid cells (ILCs) are found abundantly in the thoracic and peritoneal cavities, and they are crucial in first defense against pathogenic viruses and bacteria. Nanomaterials (NMs) can enter the cavities intentionally for medical purposes, or unintentionally following environmental exposure; subsequent serosal inflammation and cancer (mesothelioma) has gained significant interest. However, reports on adverse effects of NM on ILCs and other components of the serosal immune system are scarce or even lacking. As ILCs are crucial in the first defense against pathogenic viruses and bacteria, it is possible that serosal exposure to NM may lead to a reduced resistance against pathogens. Additionally, affected serosal lymphoid tissues and cells may disturb adipose tissue homeostasis. This review aims to provide insight into key effects of NM on the serosal immune system.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22052610