Immune Checkpoint Inhibition in Metastatic Colorectal Cancer Harboring Microsatellite Instability or Mismatch Repair Deficiency

Microsatellite instability (MSI) is a tumor phenotype related to a deficient DNA mismatch repair system (dMMR). This phenotype, observed in 5% of metastatic mCRC but 10-18% of localized CRC, is associated with high tumor mutational burden with highly immunogenic neoantigens. It has emerged as a majo...

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Bibliographic Details
Published in:Cancers 2021-03, Vol.13 (5), p.1149
Main Authors: Cohen, Romain, Colle, Raphaël, Pudlarz, Thomas, Heran, Maximilien, Duval, Alex, Svrcek, Magali, André, Thierry
Format: Article
Language:English
Subjects:
Biomarkers
Cancer immunotherapy
Chemotherapy
Colorectal cancer
Colorectal carcinoma
DNA repair
Immune checkpoint inhibitors
Immunogenicity
Life Sciences
Metastases
Metastasis
Microsatellite instability
Mismatch repair
Monoclonal antibodies
Mutation
Neoantigens
Phenotypes
Response rates
Review
Tumors
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Summary:Microsatellite instability (MSI) is a tumor phenotype related to a deficient DNA mismatch repair system (dMMR). This phenotype, observed in 5% of metastatic mCRC but 10-18% of localized CRC, is associated with high tumor mutational burden with highly immunogenic neoantigens. It has emerged as a major predictive biomarker for the efficacy of ICIs. In this review, we will present a comprehensive overview of the literature concerning the efficacy of ICIs in MSI/dMMR mCRC, with a focus on new developments in first-line metastatic setting. Then, we will present current and future challenges of immuno-oncology for patients with MSI/dMMR metastatic CRC.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13051149