Packing Density Necessary to Reach a High Complete Occlusion Rate in Circumferential Unruptured Intracranial Aneurysms Treated with Stent-Assisted Coil Embolization

• Published in: American journal of neuroradiology : AJNR 2017-10, Vol.38 (10), p.1973-1977
• Main Authors: Tosello, R T, Batista, U C, Pereira, B J A, Piske, R L
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aneurysm; Aneurysms; Cerebral Angiography; Cerebrovascular system; Circumferences; Density; Embolization; Embolization, Therapeutic - methods; Female; Humans; Implants; Interventional; Intracranial Aneurysm - therapy; Male; Middle Aged; Neck; Occlusion; On-line systems; Packing; Packing density; Predictive Value of Tests; Recurrence; Retrospective Studies; Statistical analysis; Stents; Surgical implants; Treatment Outcome
• ISSN: 0195-6108; 1936-959X
• DOI: 10.3174/ajnr.A5303

This study is a homogeneous series of circumferential unruptured intracranial aneurysms with large necks treated with stent-assisted coil embolization. Our purpose was to demonstrate which value of packing density is required to produce a durable occlusion. We retrospectively evaluated all patients with unruptured intracranial aneurysms who were treated with stent-assisted coil embolization having late angiographic control between 2004 and 2014, in a single large cerebrovascular referral center. To calculate the packing density, aneurysm volume, and coil volume, we used an on-line system. In 49 circumferential unruptured intracranial aneurysms treated with stent-assisted coil embolization, 38.7% ( = 19) had complete occlusion in the immediate control. Of those with incomplete occlusion, 80% ( = 24) progressed to complete occlusion in the late angiographic follow-up. At late angiographic control, 87.7% ( = 43) of aneurysms were completely occluded. All aneurysms with a packing density of ≥19% were completely occluded. Packing density was the only statistically significant predictor of complete occlusion. None of the aneurysms with complete occlusion at immediate control or at late angiographic control had recurrence. In circumferential aneurysms treated with stent-assisted coil embolization, packing density is the main predictor of complete occlusion. In this type of aneurysm, a packing density of ≥19% was enough to reach complete occlusion; knowing this is important to avoid higher packing densities that have more risk.