Pseudoprogression and pseudoresponse: imaging challenges in the assessment of posttreatment glioma

The current standard of care for newly diagnosed cases of high-grade glioma is surgical resection followed by RT with concurrent chemotherapy. The most widely used criteria for assessing treatment response are based on a 2D measurement of the enhancing area on MR imaging known as the Macdonald Crite...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2011-12, Vol.32 (11), p.1978-1985
Main Authors: Hygino da Cruz, Jr, L C, Rodriguez, I, Domingues, R C, Gasparetto, E L, Sorensen, A G
Format: Article
Language:English
Subjects:
Brain - pathology
Brain Neoplasms - diagnosis
Brain Neoplasms - therapy
Disease Progression
Glioma - diagnosis
Glioma - therapy
Humans
Magnetic Resonance Imaging - methods
Prognosis
Review
Treatment Outcome
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Summary:The current standard of care for newly diagnosed cases of high-grade glioma is surgical resection followed by RT with concurrent chemotherapy. The most widely used criteria for assessing treatment response are based on a 2D measurement of the enhancing area on MR imaging known as the Macdonald Criteria. Recently, nontumoral increases (pseudoprogression) and decreases (pseudoresponse) in enhancement have been found, and these can confuse outcome evaluation. Here we review pseudoprogression and pseudoresponse and describe how better understanding of these phenomena can aid interpretation.
ISSN:0195-6108
1936-959X
DOI:10.3174/ajnr.A2397